Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years
| العنوان: | Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years |
|---|---|
| المؤلفون: | Mushabbab Al Asiri, Hanadi Fatani, Ali Abdullah O Balbaid, Naji Aljohani, Yasser Bayoumi, Mutahir A. Tunio, Khalid Al-Qahtani |
| المصدر: | Clinical Interventions in Aging |
| بيانات النشر: | Dove Press, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, patients aged above 45 years, aged below 60 years, medicine.medical_treatment, Treatment outcome, Thyrotropin, Kaplan-Meier Estimate, treatment outcomes, Group A, Gastroenterology, Group B, Iodine Radioisotopes, Postoperative Complications, 0302 clinical medicine, differentiated thyroid cancers, 030212 general & internal medicine, Thyroid cancer, Original Research, Aged, 80 and over, Age Factors, clinicopathological characteristics, General Medicine, Middle Aged, Treatment Outcome, aged above 60 years, 030220 oncology & carcinogenesis, Thyroidectomy, Female, medicine.medical_specialty, comparative analysis, education, Saudi Arabia, Postoperative Hemorrhage, elderly patients, Disease-Free Survival, 03 medical and health sciences, Internal medicine, medicine, Humans, Thyroid Neoplasms, Food Contamination, Radioactive, Aged, Retrospective Studies, Hypocalcemia, business.industry, Retrospective cohort study, medicine.disease, Surgery, Hypoparathyroidism, Clinical Interventions in Aging, Geriatrics and Gerontology, business, Hormone |
| الوصف: | Khalid Hussain AL-Qahtani,1 Mutahir A Tunio,2 Mushabbab Al Asiri,2 Yasser Bayoumi,3 Ali Balbaid,2 Naji J Aljohani,4 Hanadi Fatani5 1Department of Otolaryngology-Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Department of Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia; 3Department of Radiation Oncology, NCI, Cairo University, Cairo, Egypt; 4Department of Endocrinology and Thyroid Oncology, 5Histopathology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia Introduction: The aim of this study was to evaluate the treatment outcomes of differentiated thyroid cancer in Saudi patients aged above 60 years. Materials and methods: Comparative analysis was performed in 252 patients aged 46–60 years (Group A) and 118 patients aged above 60 years (Group B), who had thyroidectomy, radioactive iodine-131, and thyroid-stimulating hormone suppression therapy between July 2000 and December 2012. Different clinicopathological features, treatment, complications, disease-free survival, and overall survival rates were compared. Results: Mean age of patients in Group A was 51.9 years (range: 46–60), and mean age of those in Group B was 68.6 years (range: 62–97). Group B patients had higher positive lymph nodes (43.2%), P=0.011. The frequency of extrathyroidal extension, multifocality, and lymphovascular space invasion was seen more in Group B than in Group A. Postsurgical complications (permanent hypoparathyroidism, bleeding, and wound infections) were also seen more in Group B (P=0.043, P=0.011, and P=0.021, respectively). Group B patients experienced more locoregional recurrences (11.0%, P=0.025); similarly, more distant metastases were observed in Group B (15.3%, P=0.003). The 10-year disease-free survival rates were 87.6% in Group A and 70.8% in Group B (P |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1178-1998 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ba028abb85d394824dcfea2bf78676Test https://www.dovepress.com/comparative-clinicopathological-and-outcome-analysis-of-differentiated-peer-reviewed-article-CIATest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a3ba028abb85d394824dcfea2bf78676 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11781998 |
|---|