Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells
| العنوان: | Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells |
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| المؤلفون: | Khalijah Awang, Noor Hasima Nagoor, Niyaz Ahmed, Lionel L. A. In, Menaga Subramaniam, Su Ki Liew |
| المصدر: | Drug Design, Development and Therapy |
| بيانات النشر: | Dove Press, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Programmed cell death, Combination therapy, Cell Survival, Mycobacterium indicus pranii, drug combination, Pharmaceutical Science, Breast Neoplasms, Microbial Sensitivity Tests, Mycobacterium, Diffusion, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Benzyl Alcohols, Cells, Cultured, Original Research, Cell Proliferation, Pharmacology, Cisplatin, Drug Design, Development and Therapy, biology, Cell Death, Dose-Response Relationship, Drug, Chemistry, Intrinsic apoptosis, NF-kappa B, Cancer, 1′S-1′-acetoxychavicol acetate, medicine.disease, biology.organism_classification, Anti-Bacterial Agents, IκBα, 030104 developmental biology, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Drug Screening Assays, Antitumor, nuclear factor κB, medicine.drug |
| الوصف: | Menaga Subramaniam,1 Su Ki Liew,1 Lionel LA In,2 Khalijah Awang,3,4 Niyaz Ahmed,5 Noor Hasima Nagoor1,6 1Institute of Biological Science (Genetics & Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia; 3Centre for Natural Product Research and Drug Discovery (CENAR), University of Malaya, Kuala Lumpur, Malaysia; 4Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; 5Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India; 6Centre for Research in Biotechnology for Agriculture (CEBAR), University of Malaya, Kuala Lumpur, Malaysia Background: Drug combination therapy to treat cancer is a strategic approach to increase successful treatment rate. Optimizing combination regimens is vital to increase therapeutic efficacy with minimal side effects. Materials and methods: In the present study, we evaluated the in vitro cytotoxicity of double and triple combinations consisting of 1'S-1'-acetoxychavicol acetate (ACA), Mycobacterium indicus pranii (MIP) and cisplatin (CDDP) against 14 various human cancer cell lines to address the need for more effective therapy. Our data show synergistic effects in MCF-7 cells treated with MIP:ACA, MIP:CDDP and MIP:ACA:CDDP combinations. The type of interaction between MIP, ACA and CDDP was evaluated based on combination index being |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1177-8881 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875915521f8fea1988b6e81e5211738fTest https://www.dovepress.com/inactivation-of-nuclear-factor-kappab-by-mip-based-drug-combinations-a-peer-reviewed-article-DDDTTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....875915521f8fea1988b6e81e5211738f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11778881 |
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