Tacrolimus versus anti-tumor necrosis factor agents for steroid-refractory active ulcerative colitis based on the severity of endoscopic findings: a single-center, open-label cohort study

التفاصيل البيبلوغرافية
العنوان: Tacrolimus versus anti-tumor necrosis factor agents for steroid-refractory active ulcerative colitis based on the severity of endoscopic findings: a single-center, open-label cohort study
المؤلفون: Takeshi Nishikawa, Hirosato Mashima, Noriyoshi Sagihara, Haruna Kawamura, Hiroyuki Miyatani, Satohiro Matsumoto
المصدر: Clinical and Experimental Gastroenterology
بيانات النشر: Dove Press, 2017.
سنة النشر: 2017
مصطلحات موضوعية: medicine.medical_specialty, Single Center, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, steroid refractory, Internal medicine, adalimumab, Remission Induction Therapy, medicine, Adalimumab, tacrolimus, Original Research, ulcerative colitis, Clinical and Experimental Gastroenterology, business.industry, Retrospective cohort study, medicine.disease, Ulcerative colitis, Infliximab, Tacrolimus, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, business, infliximab, medicine.drug, Cohort study
الوصف: Satohiro Matsumoto,Haruna Kawamura,Takeshi Nishikawa,Noriyoshi Sagihara,Hiroyuki Miyatani,Hirosato Mashima Department of Gastroenterology, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan Background and aims: At Saitama Medical Center, for remission induction in active ulcerative colitis (UC) patients with endoscopic evidence of severe disease, we tend to preferentially use tacrolimus (TAC) over anti-tumor necrosis factor (TNF)-a agents. We conducted this study to evaluate the validity of our therapeutic strategies. Patients and methods: This retrospective study was conducted in 52 steroid-refractory active UC patients with a Clinical Activity Index (CAI) score of ≥7 who were receiving remission induction therapy with TAC or anti-TNF-a agents. The patients were divided into a TAC treatment group (TAC group, n=29) and an anti-TNF-a agent treatment group (anti-TNF group, n=23). The CAI, Ulcerative Colitis Endoscopic Index of Severity (UCEIS) and incidence of events (relapse, hospitalization and surgery) were retrospectively analyzed. Results: At treatment initiation, the CAI score was 12.6 in the TAC group and 11.5 in the anti-TNF group (P=0.09), while the corresponding values of the UCEIS were 6.5 and 5.1, respectively (P=0.0035). The clinical remission rate at 12weeks was 55% (65% when only the subgroup that received rapid induction therapy was included in the analysis) in the TAC group and 57% in the anti-TNF group, with no significant difference. The cumulative event-free rates at 1, 6 and 12months were 65.5%, 39.4%, and 39.4%, respectively, in the TAC group and 95.7%, 77.2% and 71.7%, respectively, in the anti-TNF group (P=0.0037). Conclusion: Rapid induction therapy with TAC tended to be selected for active UC patients with endoscopic evidence of severe disease, and the present study supported the validity of this therapeutic approach. However, transition to the remission-maintenance phase was more favorable in the anti-TNF group. Keywords: ulcerative colitis, tacrolimus, infliximab, adalimumab, steroid refractory
وصف الملف: text/html
اللغة: English
تدمد: 1178-7023
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db0e7f122754185f8fde6eb2d224d12Test
https://www.dovepress.com/tacrolimus-versus-anti-tumor-necrosis-factor-agents-for-steroid-refrac-peer-reviewed-article-CEGTest
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....8db0e7f122754185f8fde6eb2d224d12
قاعدة البيانات: OpenAIRE