التفاصيل البيبلوغرافية
| العنوان: |
Importance of Surveillance of New Delhi Metallo-Beta-Lactamase Klebsiella pneumoniae: Molecular Characterization and Clonality of Strains Isolated in the Lazio Region, Italy. |
| المؤلفون: |
Spaziante, Martina, Venditti, Carolina, Butera, Ornella, Messina, Francesco, Caro, Antonino Di, Tonziello, Gilda, Lanini, Simone, Cataldo, Maria Adriana, Puro, Vincenzo |
| المصدر: |
Infection & Drug Resistance; Sep2021, Vol. 14, p3659-3665, 7p |
| مصطلحات موضوعية: |
KLEBSIELLA pneumoniae, CARBAPENEM-resistant bacteria, NUCLEOTIDE sequencing, DRUG resistance in microorganisms, HOSPITAL patients |
| مصطلحات جغرافية: |
NEW Delhi (India), LAZIO (Italy), ITALY |
| مستخلص: |
Introduction: New Delhi metallo-β-lactamase producing Klebsiella pneumoniae (NDM-Kpn) strains have been causing healthcare-associated infections worldwide. The aim of this study was to describe the molecular mechanisms of antimicrobial resistance and to analyze the clonality of NDM-Kpn isolates collected between January 2019 and June 2020 from patients admitted to hospitals from the Lazio region, Italy. Methods: We performed a retrospective cohort study. Whole-genome sequencing (WGS) was performed on all NDM-Kpn strains; clonality and genetic relationships were further investigated. Results: During the surveillance period, 17 NDM-Kpn isolates were obtained from 17 patients admitted to seven different hospitals. Eight different sequence types (STs) were detected: ST147 (n = 4), ST383 (n = 4), ST15 (n = 3), ST11 (n = 2), ST17 (n = 1), ST29 (n = 1), ST307 (n = 1) and the newly identified ST4853 (n = 1). Genetic relationships were further investigated by the WGS-based core genome MLST (cgMLST) scheme, and 5 cluster types (CTs) were identified. Whereas a substantial overall heterogeneity among isolates was detected (8 different STs were identified out of 17 isolates), the strains within each cluster showed a very high level of genome similarity. Discussion: Our study highlights the key role of surveillance, which allowed taking a picture of a part of the NDM-Kpn strains circulating in Italy, adding further insight into their molecular features. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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