دورية أكاديمية
NOD2 and inflammation: current insights
| العنوان: | NOD2 and inflammation: current insights |
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| المؤلفون: | Negroni A, Pierdomenico M, Cucchiara S, Stronati L |
| المصدر: | Journal of Inflammation Research, Vol Volume 11, Pp 49-60 (2018) |
| بيانات النشر: | Dove Medical Press, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Pathology LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | innate immunity, intestinal homeostasis, ER stress, autophagy, Inflammatory Bowel Disease, extra-intestinal disease, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Anna Negroni,1 Maria Pierdomenico,2 Salvatore Cucchiara,2 Laura Stronati3 1Division of Health Protection Technologies, Territorial and Production Systems Sustainability Department, ENEA, Rome, Italy; 2Department of Pediatrics and Infantile Neuropsychiatry, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy; 3Department of Cellular Biotechnology and Hematology, Sapienza University of Rome, Rome, Italy Abstract: The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory transcriptional program and other innate immune pathways, including autophagy and endoplasmic reticulum stress. An inactive form due to mutations or a constitutive high expression of NOD2 is associated with several inflammatory diseases, suggesting that balanced NOD2 signaling is critical for the maintenance of immune homeostasis. In this review, we discuss recent developments about the pathway and mechanisms of regulation of NOD2 and illustrate the principal functions of the gene, with particular emphasis on its central role in maintaining the equilibrium between intestinal microbiota and host immune responses to control inflammation. Furthermore, we survey recent studies illustrating the role of NOD2 in several inflammatory diseases, in particular, inflammatory bowel disease, of which it is the main susceptibility gene. Keywords: innate immunity, intestinal homeostasis, ER stress, autophagy, inflammatory bowel disease, extraintestinal disease |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1178-7031 |
| العلاقة: | https://www.dovepress.com/nod2-and-inflammation-current-insights-peer-reviewed-article-JIRTest; https://doaj.org/toc/1178-7031Test |
| الوصول الحر: | https://doaj.org/article/1e6e09b981304ed28217360f16abb606Test |
| رقم الانضمام: | edsdoj.1e6e09b981304ed28217360f16abb606 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11787031 |
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