Long-term (60-month) results for the implantable miniature telescope: efficacy and safety outcomes stratified by age in patients with end-stage age-related macular degeneration
| العنوان: | Long-term (60-month) results for the implantable miniature telescope: efficacy and safety outcomes stratified by age in patients with end-stage age-related macular degeneration |
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| المؤلفون: | David S. Boyer, K. Bailey Freund, Sumit Garg, Marc H Levy, Carl D. Regillo |
| المصدر: | Clinical Ophthalmology (Auckland, N.Z.) |
| بيانات النشر: | Dove Medical Press, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | medicine.medical_specialty, genetic structures, business.industry, Corneal Transplant, Subgroup analysis, Clinical Ophthalmology, Macular degeneration, medicine.disease, low vision, eye diseases, Surgery, Clinical trial, Ophthalmology, Quality of life, end-stage age-related macular degeneration, implantable miniature telescope, medicine, In patient, Stage (cooking), Adverse effect, business, Original Research |
| الوصف: | David Boyer,1 K Bailey Freund,2 Carl Regillo,3 Marc H Levy,4 Sumit Garg5 1Retina-Vitreous Associates Medical Group, Beverly Hills, CA, 2Vitreous-Retina-Macula Consultants of New York, New York, NY; 3Wills Eye Institute, Philadelphia, PA, 4Sarasota Retina Institute, Sarasota, FL, 5The Gavin Herbert Eye Institute (University of California, Irvine) Irvine, CA, USA Background: The purpose of this study was to evaluate the long-term results of an implantable miniature telescope (IMT) in patients with bilateral, end-stage, age-related macular degeneration (AMD).Methods: A prospective, open-label, multicenter clinical trial with fellow eye controls enrolled 217 patients (mean age 76 years) with AMD and moderate-to-profound bilateral central visual acuity loss (20/80–20/800) resulting from untreatable geographic atrophy, disciform scars, or both. A subgroup analysis was performed with stratification for age (patient age 65 to 30 days after surgery (7/70; 10%) and persistent corneal edema (3/70; 4.3%); and in group 2 were a decrease in BCDVA in the implanted eye or IMT removal (10/127 each; 7.9%), corneal edema >30 days after surgery (9/127; 7.1%), and persistent corneal edema (6/127; 4.7%). Significant adverse events included four corneal transplants, comprising two (2.9%) in group 1 and two (1.6%) in group 2. At 60 months, one patient in group 1 (3.2%) and three patients in group 2 (9.4%) had lost ≥2 lines of vision. The IMT was removed in one (1.4%) and ten (7.9%) patients in group 1 and group 2, respectively. Mean ECD loss was 20% at 3 months. Chronic loss was 3% per year. ECD loss was less in group 1 than in group 2 (35% versus 40%, respectively) at 60 months.Conclusion: Long-term results show substantial retention of improvement in BDCVA. Chronic ECD loss was consistent with that reported for conventional intraocular lenses. The IMT performed as well in group 1 (the younger group) as it did in group 2 through month 60. Younger patients retained more vision than their older counterparts and had fewer adverse events. Although not a specified outcome for this study, patients younger than 65 years also fared better than those in group 2 and retained more vision with fewer adverse events through month 60. Keywords: end-stage age-related macular degeneration, implantable miniature telescope, low vision |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1177-5483 1177-5467 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9bee0d51e90f10bfea256ab793f40eTest http://europepmc.org/articles/PMC4476474Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4a9bee0d51e90f10bfea256ab793f40e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11775483 11775467 |
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