Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
| العنوان: | Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma |
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| المؤلفون: | Hua Rong, Xin Mei Wang, Hong Ping Cui, Ying Hu, Hao Cui, Hai Bo Tan |
| المصدر: | Clinical Interventions in Aging |
| بيانات النشر: | Dove Medical Press, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Retinal Ganglion Cells, medicine.medical_specialty, Intraocular pressure, China, genetic structures, Short Report, Glaucoma, Cell Count, Blindness, Mesenchymal Stem Cell Transplantation, Retinal ganglion, Rats, Sprague-Dawley, Ophthalmology, medicine, Animals, Intraocular Pressure, business.industry, Mesenchymal stem cell, aging, General Medicine, medicine.disease, eye diseases, Surgery, Rats, Transplantation, stem cell, medicine.anatomical_structure, Treatment Outcome, Retinal ganglion cell, Clinical Interventions in Aging, Models, Animal, Bone marrow, sense organs, Geriatrics and Gerontology, Stem cell, cell therapy, business, transplantation |
| الوصف: | Ying Hu,1,2 Hai Bo Tan,1 Xin Mei Wang,3 Hua Rong,1 Hong Ping Cui,1 Hao Cui2 Departments of Ophthalmology, 1Shanghai East Hospital of Tongji University, Shanghai, 2First Affiliated Hospital, 3Fourth Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China Abstract: Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma. Keywords: glaucoma, stem cell, transplantation, cell therapy, aging |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1178-1998 1176-9092 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d52c401336833653be101d83d5cb67cTest http://europepmc.org/articles/PMC3817004Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0d52c401336833653be101d83d5cb67c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11781998 11769092 |
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