Core-shell hybrid liposomal vesicles loaded with panax notoginsenoside: preparation, characterization and protective effects on global cerebral ischemia/reperfusion injury and acute myocardial ischemia in rats
| العنوان: | Core-shell hybrid liposomal vesicles loaded with panax notoginsenoside: preparation, characterization and protective effects on global cerebral ischemia/reperfusion injury and acute myocardial ischemia in rats |
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| المؤلفون: | Han Xizhen, Zheng-Gen Liao, Zhao Haiping, Yun Luo, Jing Zhang, Xiang Li, Ming Yang, Bin Ni |
| المصدر: | International Journal of Nanomedicine |
| بيانات النشر: | Dove Medical Press, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | liposomes, Brain Infarction, Male, animal structures, Cardiotonic Agents, Ginsenosides, in vivo animal models, Biophysics, Ischemia, Myocardial Ischemia, Pharmaceutical Science, Bioengineering, physicochemical properties, Pharmacology, Antioxidants, Brain Ischemia, Biomaterials, Brain ischemia, Rats, Sprague-Dawley, Drug Stability, International Journal of Nanomedicine, Oral administration, In vivo, Edema, Drug Discovery, medicine, Animals, Original Research, Brain Chemistry, Liposome, Analysis of Variance, L-Lactate Dehydrogenase, business.industry, Organic Chemistry, panax notoginsenoside, Water, General Medicine, medicine.disease, Bioavailability, Rats, nervous system, Reperfusion Injury, nanoparticles, medicine.symptom, business, Reperfusion injury, Drugs, Chinese Herbal |
| الوصف: | Jing Zhang,1,* Xizhen Han,1,* Xiang Li,2 Yun Luo,1 Haiping Zhao,1 Ming Yang,1 Bin Ni,1 Zhenggen Liao11Key Laboratory of Modern Preparation of TCM, Ministry of Education, 2National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of China*These authors contributed equally to this workPurpose: Novel panax notoginsenoside-loaded core-shell hybrid liposomal vesicles (PNS-HLV) were developed to resolve the restricted bioavailability of PNS and to enhance its protective effects in vivo on oral administration.Methods: Physicochemical characterizations of PNS-HLV included assessment of morphology, particle size and zeta potential, encapsulation efficiency (EE%), stability and in vitro release study. In addition, to evaluate its oral treatment potential, we compared the effect of PNS-HLV on global cerebral ischemia/reperfusion and acute myocardial ischemia injury with those of PNS solution, conventional PNS-loaded nanoparticles, and liposomes.Results: In comparison with PNS solution, conventional PNS-loaded nanoparticles and liposomes, PNS-HLV was stable for at least 12 months at 4°C. Satisfactory improvements in the EE% of notoginsenoside R1, ginsenoside Rb1, and ginsenoside Rg1 were shown with the differences in EE% shortened and the greater controlled drug release profiles were exhibited from PNS-HLV. The improvements in the physicochemical properties of HLV contributed to the results that PNS-HLV was able to significantly inhibit the edema of brain and reduce the infarct volume, while it could markedly inhibit H2O2, modified Dixon agar, and serum lactate dehydrogenase, and increase superoxide dismutase (P < 0.05).Conclusion: The results of the present study imply that HLV has promising prospects for improving free drug bioactivity on oral administration.Keywords: liposomes, nanoparticles, panax notoginsenoside, physicochemical properties, in vivo animal models |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1178-2013 1176-9114 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dcc47b5c6b14d0c6bb396b2be8b270bTest http://europepmc.org/articles/PMC3419509Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2dcc47b5c6b14d0c6bb396b2be8b270b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11782013 11769114 |
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