دورية أكاديمية
A Polygenic Risk Score of atrial Fibrillation Improves Prediction of Lifetime Risk For Heart Failure
| العنوان: | A Polygenic Risk Score of atrial Fibrillation Improves Prediction of Lifetime Risk For Heart Failure |
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| المؤلفون: | Alkis, Taryn, Luo, Xi, Wall, Katherine, Brody, Jennifer, Bartz, Traci, Chang, Patricia P, Norby, Faye L, Hoogeveen, Ron C, Morrison, Alanna C, Ballantyne, Christie M, Coresh, Josef, Boerwinkle, Eric, Psaty, Bruce M, Shah, Amil M, Yu, Bing |
| المصدر: | Journal Articles |
| بيانات النشر: | DigitalCommons@TMC |
| سنة النشر: | 2024 |
| المجموعة: | Houston Academy of Medicine-Texas Medical Center (HAM-TMC): DigitalCommons@The Texas Medical Center |
| مصطلحات موضوعية: | Humans, Atrial Fibrillation, Genetic Risk Score, Diabetes Mellitus, Type 2, Heart Failure, Risk Factors, Atherosclerosis, Coronary Disease, Medicine and Health Sciences, Public Health |
| الوصف: | AIMS: Heart failure (HF) has shared genetic architecture with its risk factors: atrial fibrillation (AF), body mass index (BMI), coronary heart disease (CHD), systolic blood pressure (SBP), and type 2 diabetes (T2D). We aim to assess the association and risk prediction performance of risk-factor polygenic risk scores (PRSs) for incident HF and its subtypes in bi-racial populations. METHODS AND RESULTS: Five PRSs were constructed for AF, BMI, CHD, SBP, and T2D in White participants of the Atherosclerosis Risk in Communities (ARIC) study. The associations between PRSs and incident HF and its subtypes were assessed using Cox models, and the risk prediction performance of PRSs was assessed using C statistics. Replication was performed in the ARIC study Black and Cardiovascular Health Study (CHS) White participants. In 8624 ARIC study Whites, 1922 (31% cumulative incidence) HF cases developed over 30 years of follow-up. PRSs of AF, BMI, and CHD were associated with incident HF (P < 0.001), where PRS CONCLUSIONS: The PRS |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.library.tmc.edu/uthsph_docs/426Test; https://digitalcommons.library.tmc.edu/context/uthsph_docs/article/1416/viewcontent/EHF2_11_1086.pdfTest |
| الإتاحة: | https://digitalcommons.library.tmc.edu/uthsph_docs/426Test https://digitalcommons.library.tmc.edu/context/uthsph_docs/article/1416/viewcontent/EHF2_11_1086.pdfTest |
| رقم الانضمام: | edsbas.D267AC3F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |