دورية أكاديمية
Chemoradiation Therapy Alters the Pd-l1 Score in Locoregional Recurrent Squamous Cell Carcinomas of the Head and Neck
| العنوان: | Chemoradiation Therapy Alters the Pd-l1 Score in Locoregional Recurrent Squamous Cell Carcinomas of the Head and Neck |
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| المؤلفون: | Park, Brian J, Mattox, Austin K, Clayburgh, Daniel, Patel, Mihir, Bell, R Bryan, Yueh, Bevan, Leidner, Rom, Xiao, Hong, Couey, Marcus, Li, Shiting, Qin, Tingting, Sartor, Maureen A, Cairns, Belinda, MacDonough, Tracy, Halliwill, Kyle, Deschler, Daniel, Lin, Derrick T, Faquin, William C, Sadow, Peter M, Pai, Sara I |
| المصدر: | Journal Articles |
| بيانات النشر: | DigitalCommons@TMC |
| سنة النشر: | 2022 |
| المجموعة: | Houston Academy of Medicine-Texas Medical Center (HAM-TMC): DigitalCommons@The Texas Medical Center |
| مصطلحات موضوعية: | Humans, B7-H1 Antigen, Squamous Cell Carcinoma of Head and Neck, Neoplasm Recurrence, Local, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Medical Specialties, Medicine and Health Sciences, Oncology, Otolaryngology, Radiology |
| الوصف: | PD-L1 testing guides therapeutic decision-making for head and neck squamous cell carcinoma (HNSCC). We sought to understand whether chemoradiation therapy (CRT) influences the PD-L1 combined positive score (CPS) and other biomarkers of response to immunotherapy. PD-L1 expression was assessed using immunohistochemistry, and bulk RNA sequencing was performed on 146 HNSCC patients (65 primary sites, 50 paired local recurrences, and 31 paired regional recurrences). PD-L1 was scored using the CPS of ≥1, ≥20, and ≥50. Overall, 98 %, 54 %, and 17 % of HNSCCs had a CPS ≥1, ≥20, and ≥50, respectively. When using a cut-off of ≥1, CRT did not significantly change CPS at the locoregional recurrent site. However, there were significant changes when using CPS ≥20 or ≥50. The CPS changed for 32 % of patients when using a CPS ≥20 (p < 0.001). When using a CPS ≥50, there was a 20-23 % (p = 0.0058-0.00067) discordance rate at the site of locoregional recurrence. Oral cavity cancers had a significantly higher discordant rate than other primary sites for CPS ≥50, 44 % (8/18, p = 0.0058) and 58 % (7/12, p = 0.00067) discordance at the site of local and regional recurrence, respectively. When evaluating the 18 gene IFN-É£ signature predictive of response to anti-PD-1 blockade, there was a statistically significant increase in the IFN-É£ signature in recurrent larynx cancer (p = 0.02). Our study demonstrates that when using a higher cut-off of CPS ≥20 and ≥50, a repeat biopsy may be warranted after CRT for local and regional recurrent HNSCCs. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.library.tmc.edu/uthmed_docs/1141Test; https://digitalcommons.library.tmc.edu/context/uthmed_docs/article/2120/viewcontent/nihms_1905808.pdfTest |
| الإتاحة: | https://digitalcommons.library.tmc.edu/uthmed_docs/1141Test https://digitalcommons.library.tmc.edu/context/uthmed_docs/article/2120/viewcontent/nihms_1905808.pdfTest |
| رقم الانضمام: | edsbas.D417958D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |