دورية أكاديمية
Day and night closed-loop control in adults with type 1 diabetes: a comparison of two closed-loop algorithms driving continuous subcutaneous insulin infusion versus patient self-management.
| العنوان: | Day and night closed-loop control in adults with type 1 diabetes: a comparison of two closed-loop algorithms driving continuous subcutaneous insulin infusion versus patient self-management. |
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| المؤلفون: | Luijf, Yoeri M, DeVries, J Hans, Zwinderman, Koos, Leelarathna, Lalantha, Nodale, Marianna, Caldwell, Karen, Kumareswaran, Kavita, Elleri, Daniela, Allen, Janet M, Wilinska, Malgorzata E, Evans, Mark L, Hovorka, Roman, Doll, Werner, Ellmerer, Martin, Mader, Julia K, Renard, Eric, Place, Jerome, Farret, Anne, Cobelli, Claudio, Del Favero, Simone, Dalla Man, Chiara, Avogaro, Angelo, Bruttomesso, Daniela, Filippi, Alessio, Scotton, Rachele, Magni, Lalo, Lanzola, Giordano, Di Palma, Federico, Soru, Paola, Toffanin, Chiara, De Nicolao, Giuseppe, Arnolds, Sabine, Benesch, Carsten, Heinemann, Lutz, AP@home Consortium |
| بيانات النشر: | American Diabetes Association //dx.doi.org/10.2337/dc12-1956 Diabetes Care |
| سنة النشر: | 2013 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Administration, Cutaneous, Adult, Algorithms, Blood Glucose, Blood Glucose Self-Monitoring, Cross-Over Studies, Diabetes Mellitus, Type 1, Equipment Design, Female, Follow-Up Studies, Humans, Hypoglycemic Agents, Infusion Pumps, Insulin, Insulin Infusion Systems, Male, Self Care, Treatment Outcome |
| الوصف: | OBJECTIVE: To compare two validated closed-loop (CL) algorithms versus patient self-control with CSII in terms of glycemic control. RESEARCH DESIGN AND METHODS: This study was a multicenter, randomized, three-way crossover, open-label trial in 48 patients with type 1 diabetes mellitus for at least 6 months, treated with continuous subcutaneous insulin infusion. Blood glucose was controlled for 23 h by the algorithm of the Universities of Pavia and Padova with a Safety Supervision Module developed at the Universities of Virginia and California at Santa Barbara (international artificial pancreas [iAP]), by the algorithm of University of Cambridge (CAM), or by patients themselves in open loop (OL) during three hospital admissions including meals and exercise. The main analysis was on an intention-to-treat basis. Main outcome measures included time spent in target (glucose levels between 3.9 and 8.0 mmol/L or between 3.9 and 10.0 mmol/L after meals). RESULTS: Time spent in the target range was similar in CL and OL: 62.6% for OL, 59.2% for iAP, and 58.3% for CAM. While mean glucose level was significantly lower in OL (7.19, 8.15, and 8.26 mmol/L, respectively) (overall P = 0.001), percentage of time spent in hypoglycemia (<3.9 mmol/L) was almost threefold reduced during CL (6.4%, 2.1%, and 2.0%) (overall P = 0.001) with less time ≤2.8 mmol/L (overall P = 0.038). There were no significant differences in outcomes between algorithms. CONCLUSIONS: Both CAM and iAP algorithms provide safe glycemic control. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/302219Test |
| DOI: | 10.17863/CAM.49293 |
| الإتاحة: | https://doi.org/10.17863/CAM.49293Test https://www.repository.cam.ac.uk/handle/1810/302219Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.12732C69 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.49293 |
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