دورية أكاديمية
The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling.
| العنوان: | The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling. |
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| المؤلفون: | Birdsey, Graeme M, Shah, Aarti V, Dufton, Neil, Reynolds, Louise E, Osuna Almagro, Lourdes, Yang, Youwen, Aspalter, Irene M, Khan, Samia T, Mason, Justin C, Dejana, Elisabetta, Göttgens, Berthold, Hodivala-Dilke, Kairbaan, Gerhardt, Holger, Adams, Ralf H, Randi, Anna M |
| بيانات النشر: | Elsevier BV //dx.doi.org/10.1016/j.devcel.2014.11.016 Dev Cell |
| سنة النشر: | 2015 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Animals, Antigens, CD, Blotting, Western, Cadherins, Cells, Cultured, Chromatin Immunoprecipitation, Endothelium, Vascular, Female, Frizzled Receptors, Human Umbilical Vein Endothelial Cells, Humans, Integrases, Lung, Mice, Transgenic, Neovascularization, Physiologic, Oncogene Proteins, Pregnancy, Real-Time Polymerase Chain Reaction, Signal Transduction, Transcription Factors, Transcriptional Regulator ERG, Vascular Endothelial Growth Factor A, Wnt Proteins, beta Catenin |
| الوصف: | Blood vessel stability is essential for embryonic development; in the adult, many diseases are associated with loss of vascular integrity. The ETS transcription factor ERG drives expression of VE-cadherin and controls junctional integrity. We show that constitutive endothelial deletion of ERG (Erg(cEC-KO)) in mice causes embryonic lethality with vascular defects. Inducible endothelial deletion of ERG (Erg(iEC-KO)) results in defective physiological and pathological angiogenesis in the postnatal retina and tumors, with decreased vascular stability. ERG controls the Wnt/β-catenin pathway by promoting β-catenin stability, through signals mediated by VE-cadherin and the Wnt receptor Frizzled-4. Wnt signaling is decreased in ERG-deficient endothelial cells; activation of Wnt signaling with lithium chloride, which stabilizes β-catenin levels, corrects vascular defects in Erg(cEC-KO) embryos. Finally, overexpression of ERG in vivo reduces permeability and increases stability of VEGF-induced blood vessels. These data demonstrate that ERG is an essential regulator of angiogenesis and vascular stability through Wnt signaling. ; This work was funded by grants from the British Heart Foundation (PG/09/096 and RG/11/17/29256). A.V.S. is a recipient of a National Lung and Heart Institute Foundation Studentship. I.M.A. is a recipient of a DOC-fFORTE fellowship of the Austrian Academy of Sciences at the London Research Institute. ; This paper was published by Cell Press in Developmental Cell (GM Birdsey, AV Shah, N Dufton, LE Reynolds, LO Almagro, Y Yang, IM Aspalter, ST Khan, JC Mason, E Dejana, B Göttgens, K Hodivala-Dilke, Gerhardt, RH Adams, AM Randi, Developmental Cell 2015, 32, 82-96) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/246789Test |
| الإتاحة: | https://www.repository.cam.ac.uk/handle/1810/246789Test |
| حقوق: | Attribution 2.0 UK: England & Wales ; http://creativecommons.org/licenses/by/2.0/ukTest/ |
| رقم الانضمام: | edsbas.74C4B7F9 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |