دورية أكاديمية
A survey of bacterial, fungal and plant metabolites against Aedes aegypti (Diptera: Culicidae), the vector of yellow and dengue fevers and Zika virus
| العنوان: | A survey of bacterial, fungal and plant metabolites against Aedes aegypti (Diptera: Culicidae), the vector of yellow and dengue fevers and Zika virus |
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| المؤلفون: | Masi Marco, Cimmino Alessio, Tabanca Nurhayat, Becnel James J., Bloomquist Jeffrey R., Evidente Antonio |
| المصدر: | Open Chemistry, Vol 15, Iss 1, Pp 156-166 (2017) |
| بيانات النشر: | De Gruyter, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | secondary metabolites, mosquito control, biopesticides, microbial and plant derived natural products, Chemistry, QD1-999 |
| الوصف: | Aedes aegypti L. is the major vector of the arboviruses responsible for dengue fever, one of the most devastating human diseases. Some bacterial, fungal and plant metabolites belonging to different chemical subgroups, including Amaryllidaceae alkaloids, anthracenes, azoxymethoxytetrahydropyrans, cytochalasans, 2,5-diketopiperazines, isochromanones, naphthoquinones, organic small acids and their methyl esters, sterols and terpenes including sesquiterpenes and diterpenes, were tested for their larvicidal and adulticidal activity against Ae. aegypti. Out of 23 compounds tested, gliotoxin exhibited mosquitocidal activity in both bioassays with an LC50 value of 0.0257 ± 0.001 µg/µL against 1st instar Ae. aegypti and LD50 value of 2.79 ± 0.1197 µg/mosquito against adult female Ae. aegypti. 2-Methoxy-1,4-naphthoquinone and cytochalasin A showed LC50 values of 0.0851 ± 0.0012 µg/µL and 0.0854 ± 0.0019 µg/µL, respectively, against Ae. aegypti larvae. In adult bioassays, fusaric acid (LD50= 0.8349 ± 0.0118 µg/mosquito), 3-nitropropionic acid (LD50 = 1.6641 ± 0.0494 µg/mosquito) and α-costic acid (LD50 = 2.547 ± 0.0835 µg/mosquito) exhibited adulticidal activity. Results from the current study confirm that compounds belonging to cytochalsin, diketopiperazine, naphthoquinone and low molecular weight organic acid groups are active and may stimulate further SAR investigations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2391-5420 94439850 |
| العلاقة: | http://www.degruyter.com/view/j/chem.2017.15.issue-1/chem-2017-0019/chem-2017-0019.xml?format=INTTest; https://doaj.org/toc/2391-5420Test |
| DOI: | 10.1515/chem-2017-0019 |
| الوصول الحر: | https://doaj.org/article/5c174adc24c9443985079b50ff1e8800Test |
| رقم الانضمام: | edsdoj.5c174adc24c9443985079b50ff1e8800 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23915420 94439850 |
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| DOI: | 10.1515/chem-2017-0019 |