دورية أكاديمية
Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population
| العنوان: | Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population |
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| المؤلفون: | White, Marquitta J, Kodaman, Nuri M, Harder, Reed H, Asselbergs, Folkert W, Vaughan, Douglas E, Brown, Nancy J, Moore, Jason H, Williams, Scott M |
| المصدر: | Dartmouth Scholarship |
| بيانات النشر: | Dartmouth Digital Commons |
| سنة النشر: | 2015 |
| المجموعة: | Dartmouth Digital Commons (Dartmouth College) |
| مصطلحات موضوعية: | adult, cardiovascular diseases, circadian rhythm, european continental ancestry group, female, ghana, humans, male, n-acetylgalactosamine-4-sulfatase, period circadian proteins, plasminogen activator inhibitor 1, polymorphism, single nucleotide, per3 protein, human, serpine1 protein, arsb protein, Life Sciences, Medicine and Health Sciences |
| الوصف: | Plasminogen activator inhibitor 1 (PAI-1), a major modulator of the fibrinolytic system, is an important factor in cardiovascular disease (CVD) susceptibility and severity. PAI-1 is highly heritable, but the few genes associated with it explain only a small portion of its variation. Studies of PAI-1 typically employ linear regression to estimate the effects of genetic variants on PAI-1 levels, but PAI-1 is not normally distributed, even after transformation. Therefore, alternative statistical methods may provide greater power to identify important genetic variants. Additionally, most genetic studies of PAI-1 have been performed on populations of European descent, limiting the generalizability of their results. We analyzed > 30,000 variants for association with PAI-1 in a Ghanaian population, using median regression, a non- parametric alternative to linear regression. Three variants associated with median PAI-1, the most significant of which was in the gene arylsulfatase B ( ARSB ) (p = 1.09 x 10−7). We also analyzed the upper quartile of PAI-1, the most clinically relevant part of the distribution, and found 19 SNPs significantly associated in this quartile. Of note an association was found in period circadian clock 3 (PER3 ). Our results reveal novel associations with median and elevated PAI-1 in an understudied population. The lack of overlap between the two analyses indicates that the genetic effects on PAI-1 are not uniform across its distribution. They also provide evidence of the generalizability of the circadian pathway’s effect on PAI-1, as a recent meta-analysis performed in Caucasian populations identified another circadian clock gene (ARNTL). |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.dartmouth.edu/facoa/2737Test; https://digitalcommons.dartmouth.edu/context/facoa/article/3751/viewcontent/ptpmcrender.fcgiTest |
| DOI: | 10.1371/journal.pone.0136379 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0136379Test https://digitalcommons.dartmouth.edu/facoa/2737Test https://digitalcommons.dartmouth.edu/context/facoa/article/3751/viewcontent/ptpmcrender.fcgiTest |
| رقم الانضمام: | edsbas.6744AC26 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0136379 |
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