Identification of high-risk patients by human epididymis protein 4 levels during follow-up of ovarian cancer
| العنوان: | Identification of high-risk patients by human epididymis protein 4 levels during follow-up of ovarian cancer |
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| المؤلفون: | Ivan Brandslund, Karina Dahl Steffensen, Anders Jakobsen, Sarah Mejer Sørensen, Max Petzold, Marianne Waldstrøm, Bente Lund |
| المصدر: | Oncology Letters Dahl Steffensen, K, Waldstrøm, M, Brandslund, I, Lund, B, Mejer Sørensen, S, Petzold, M & Jakobsen, A 2016, ' Identification of high-risk patients by human epididymis protein 4 levels during follow-up of ovarian cancer ', Oncology Letters, vol. 11, no. 6, pp. 3967-3974 . https://doi.org/10.3892/ol.2016.4533Test Dahl Steffensen, K, Waldstrøm, M, Brandslund, I, Lund, B, Sørensen, S M, Petzold, M & Jakobsen, A 2016, ' Identification of high-risk patients by human epididymis protein 4 levels during follow-up of ovarian cancer ', Oncology Letters, vol. 11, no. 6, pp. 3967-3974 . https://doi.org/10.3892/ol.2016.4533Test |
| بيانات النشر: | D.A. Spandidos, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, medicine.medical_specialty, Multivariate analysis, recurrence, medicine.medical_treatment, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, follow-up, human epididymis protein 4, carbohydrate antigen 125, Gynecology, Chemotherapy, business.industry, Hazard ratio, Cancer, Articles, medicine.disease, Molecular medicine, Carboplatin, 030104 developmental biology, ovarian cancer, Oncology, chemistry, 030220 oncology & carcinogenesis, Biomarker (medicine), biomarker, business, Ovarian cancer |
| الوصف: | The majority of ovarian cancer patients with advanced disease at diagnosis will relapse following primary treatment, with a dismal prognosis. Monitoring the levels of serum markers in patients under follow-up may be essential for the early detection of relapse, and for distinguishing high-risk patients from those with less aggressive disease. The aim of the present study was to investigate the possible predictive value of human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) in relation to recurrence of epithelial ovarian cancer by measuring the two markers during follow-up subsequent to surgery and adjuvant first-line carboplatin/paclitaxel chemotherapy. Serum HE4 and CA125 were analyzed in 88 epithelial ovarian cancer patients at the end of treatment and consecutively during follow-up. The patients were divided into a high-risk and a low-risk group based on having an increase in HE4 and CA125 levels above or below 50% during follow-up, relative to the baseline (end-of-treatment) level. Disease recurrence was detected in 55 patients during follow-up. Patients with an increase in HE4 of >50% at 3- and 6-month follow-up compared to the end-of-treatment sample had significantly poorer progression-free survival (PFS) [hazard ratio (HR), 2.82 (95% CI, 0.91-8.79; P=0.0052) and HR, 7.71 (95% CI, 3.03-19.58; P50%) showed HRs of 1.86 (95% CI, 0.90-3.80; P=0.0512) and 2.55 (95% CI, 1.39-4.68; P=0.0011), respectively. Multivariate analysis confirmed HE4 as a predictor of short PFS, with an HR of 8.23 (95% CI, 3.28-20.9; P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1792-1082 1792-1074 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5b4a7e08085f790fa2c1a390214795Test http://europepmc.org/articles/PMC4888273Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0d5b4a7e08085f790fa2c1a390214795 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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