Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas
| العنوان: | Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas |
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| المؤلفون: | Andrzej Slominski, Anna A. Brożyna, Cezary Jochymski, Wojciech Jóźwicki |
| المصدر: | Oncology Reports |
| بيانات النشر: | D.A. Spandidos, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Cancer Research, medicine.medical_specialty, Calcitriol, vitamin D, Biology, Ovarian tumor, Young Adult, CYP27B1, Internal medicine, medicine, polycyclic compounds, Tumor Microenvironment, Humans, Neoplasm Metastasis, Aged, Cell Proliferation, 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Ovarian Neoplasms, Tumor microenvironment, ovarian cancers, Oncogene, Tumor-infiltrating lymphocytes, Carcinoma, Cancer, prognostic factors, General Medicine, Articles, Cell cycle, Middle Aged, medicine.disease, Molecular medicine, Survival Analysis, Endocrinology, Oncology, embryonic structures, Cancer research, lipids (amino acids, peptides, and proteins), Female, medicine.drug |
| الوصف: | CYP27B1 hydroxylates 25-hydroxyvitamin D3 in position C1α into biologically active 1,25-dihydroxyvitamin D3, calcitriol. CYP27B1 is expressed in normal tissues and tumors. Since calcitriol indicates anticancer activities and CYP27B1 expression can be deregulated during malignant progression, we analyzed its expression in ovarian cancers in relation to pathomorphological features of tumors and overall survival (OS). Expression of CYP27B1 was evaluated in 61 ovarian tumors, 18 metastases and 10 normal ovaries. Normal ovarian epithelium showed the highest levels CYP27B1 with a significant decrease in its expression in ovarian cancers. Both poorly differentiated primary tumors and metastases showed the lowest level of CYP27B1 expression, while non-metastasizing tumors showed a higher CYP27B1 level than tumors that developed metastases. The expression of CYP27B1 was positively correlated with a lower proliferation rate, lower dynamism of tumor growth and tumor infiltrating lymphocyte response. Furthermore, CYP27B1 expression was negatively correlated with tumor cell modeling of their microenvironment. CYP27B1 expression was also associated with longer OS time. In summary, our results suggest that local expression of CYP27B1 in ovarian tumor cells can modify their behavior and promote a less aggressive phenotype by affecting local concentrations of active of vitamin D levels within the tumor microenvironment. |
| اللغة: | English |
| تدمد: | 1791-2431 1021-335X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f959a6a5779883d128e31b2ed24fc0e5Test http://europepmc.org/articles/PMC4306272Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f959a6a5779883d128e31b2ed24fc0e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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