Prognostic and therapeutic role of HER2 expression in micropapillary carcinoma of the bladder
| العنوان: | Prognostic and therapeutic role of HER2 expression in micropapillary carcinoma of the bladder |
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| المؤلفون: | Luigi Cormio, Giuseppe Carrieri, Francesca Sanguedolce, Beppe Calò, Davide Russo, Vito Mancini, Oscar Selvaggio |
| المصدر: | Molecular and Clinical Oncology |
| بيانات النشر: | D.A. Spandidos, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, 030232 urology & nephrology, Disease, Review, human epidermal growth factor receptor-2, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Stage (cooking), Micropapillary carcinoma, micropapillary variant, Her2 expression, Bladder cancer, business.industry, Cancer, medicine.disease, Molecular medicine, 030220 oncology & carcinogenesis, immunohistochemistry, Immunohistochemistry, bladder cancer, in situ hybridization, business |
| الوصف: | Micropapillary carcinoma of the bladder (MPBC) is a variant type of infiltrating urothelial carcinoma, which portends a poor biological behavior in terms of disease stage at first diagnosis and clinical outcome; its peculiar morphology raises issues concerning the ability of tumor detection by imaging techniques and proper biopsy procedure, and the appropriate treatment for non-muscle infiltrating and muscle-infiltrating MPBC remains a matter of debate. On the basis of its established prognostic and therapeutic role in breast and gastro-esophageal cancer in the first instance, the human epidermal growth factor receptor-2 (HER2) has been investigated in selected case series of MPBC over the last 10 years. The aim of the present review was to summarize the existing evidence on HER2 status in MPBC, and to discuss its present and future utility in risk assessment and treatment choice of this uncommon, yet aggressive, disease. |
| اللغة: | English |
| تدمد: | 2049-9469 2049-9450 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9887f9536dfb2c61f027f262a07808d8Test http://europepmc.org/articles/PMC6327213Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9887f9536dfb2c61f027f262a07808d8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20499469 20499450 |
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