Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor
| العنوان: | Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor |
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| المؤلفون: | Jing Tang, Weiwei Yang, Yu Liu, Dandan Tong, Duanyang Liu, Ming Li, Ya-nan Liang, Xiaoming Jin |
| المصدر: | Oncology Letters |
| بيانات النشر: | D.A. Spandidos, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, caveolin-1, Biology, medicine.disease_cause, Papillary thyroid cancer, 03 medical and health sciences, 0302 clinical medicine, medicine, papillary thyroid cancer, Epidermal growth factor receptor, RAB11 family interacting protein 3, Oncogene, Articles, Cell cycle, medicine.disease, Molecular medicine, EH domain-containing 1, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Caveolin 1, Cancer research, biology.protein, Immunohistochemistry, Carcinogenesis, epidermal growth factor receptor |
| الوصف: | Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and it is often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain-containing 1 (EHD1) is associated with EGFR-mediated endocytotic recycling in multiple tumor types. The objective of the present study was to determine the protein expression levels and clinical significance of EHD1, EGFR, caveolin-1 (CAV-1) and RAB11 family interacting protein 3 (RAB11FIP3) in PTC. PTC specimens were analyzed for EHD1, EGFR, CAV-1 and RAB11FIP3 expression via immunohistochemistry and western blotting. The associations between protein expression and clinicopathological features were assessed. EHD1, EGFR, CAV-1 and RAB11FIP3 expression levels were increased in human PTC. Additionally, the expression level of EHD1 protein was significantly associated with tumor size, lymph node metastasis and EGFR expression (P |
| اللغة: | English |
| تدمد: | 1792-1082 1792-1074 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82036e0cc51f86d340fae487f5735161Test http://europepmc.org/articles/PMC6126170Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....82036e0cc51f86d340fae487f5735161 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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