Human immunodeficiency virus-negative plasmablastic lymphoma: A comprehensive analysis of 114 cases
| العنوان: | Human immunodeficiency virus-negative plasmablastic lymphoma: A comprehensive analysis of 114 cases |
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| المؤلفون: | Qiang Wang, Bin Liu, Lijuan Ding, Bailong Liu, Min Liu, Lihua Dong, Cheng-Cheng Xia |
| المصدر: | Oncology Reports |
| بيانات النشر: | D.A. Spandidos, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Cancer Research, Epstein-Barr Virus Infections, Herpesvirus 4, Human, medicine.medical_treatment, Kaplan-Meier Estimate, Gastroenterology, Organ transplantation, Postoperative Complications, Bone Marrow, Antineoplastic Combined Chemotherapy Protocols, Young adult, Child, Aged, 80 and over, treatment, Remission Induction, Immunosuppression, HIV negative, Neoplasms, Second Primary, General Medicine, Articles, Herpesviridae Infections, Middle Aged, Prognosis, Combined Modality Therapy, medicine.anatomical_structure, Oncology, Child, Preschool, Herpesvirus 8, Human, Female, Adult, medicine.medical_specialty, Adolescent, etiology, plasmablastic lymphoma, Immunocompromised Host, Young Adult, Age Distribution, Internal medicine, HIV Seronegativity, medicine, Humans, Sex Distribution, Epstein–Barr virus infection, Aged, Neoplasm Staging, Proportional Hazards Models, Proportional hazards model, business.industry, Cancer, Organ Transplantation, medicine.disease, Immunology, Bone marrow, business, Plasmablastic lymphoma, clinicopathological features |
| الوصف: | Human immunodeficiency virus-negative plasmablastic lymphoma (PBL) is an extremely rare entity. Its clinicopathological features, optimal treatment strategy and prognostic factors remain obsure. An extensive search was performed in the English language literature within the Pubmed database using the key words: ‘plasmablastic lymphoma and human immunodeficiency virus-negative or immunocompetent’. Data from 114 patients from 52 articles were analyzed. The mean patient age at diagnosis was 58.90 years (range, 2–86). HIV-negative PBL showed a predilection for elderly individuals (patients older than 60 years, 56.14%) and affected more males than females (M:F, 2.29:1). Ann Arbor stage IV patients accounted for 39.22% while bone marrow involvement was less frequent (12.79%). The Ki-67 index was high with a mean expression of 83%. Epstein-Barr virus (EBV) infection was common being positive in 58.70% of the patients while herpesvirus-8 (HHV-8) infection was rare being positive in only 7.55% of the patients. Immunosuppression was noted in 28.16% of patients. The median overall survival (OS) was 19 months. The 1- and 2-year survival rates were 52.3 and 45.3%, respectively. Age, gender and primary site showed no strong relationship with OS while Immunosuppression, Ann Arbor stage IV and EBV negativity were able to predict a poorer OS. Either complete remission (CR) or partial remission (PR) was superior to the refractory group in OS (P |
| اللغة: | English |
| تدمد: | 1791-2431 1021-335X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d6769f85db1086e58d89412f83eb11Test http://europepmc.org/articles/PMC4358079Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....01d6769f85db1086e58d89412f83eb11 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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