PTPRQ as a potential biomarker for idiopathic normal pressure hydrocephalus
| العنوان: | PTPRQ as a potential biomarker for idiopathic normal pressure hydrocephalus |
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| المؤلفون: | Kotaro Hattori, Sumiko Yoshida, Yuki Nagata, Shumpei Niida, Saiko Sugiura, Masahiro Kamita, Masaya Ono, Yu-ichi Goto, Katsuya Urakami, Masahiko Bundo |
| المصدر: | Molecular Medicine Reports |
| بيانات النشر: | D.A. Spandidos, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Cancer Research, Pathology, medicine.medical_specialty, Urinary incontinence, Disease, Biology, Biochemistry, Gastroenterology, cerebrospinal fluid, 03 medical and health sciences, Mice, 0302 clinical medicine, Cerebrospinal fluid, Hearing, Internal medicine, Genetics, medicine, Dementia, Animals, Humans, Molecular Biology, PTPRQ, Aged, diagnostic marker, Receptor-Like Protein Tyrosine Phosphatases, Class 3, Brain, Reproducibility of Results, Articles, medicine.disease, Hydrocephalus, Normal Pressure, Hydrocephalus, shunt non-responder, 030104 developmental biology, Oncology, Potential biomarkers, (Idiopathic) normal pressure hydrocephalus, Molecular Medicine, Biomarker (medicine), Audiometry, Pure-Tone, Female, medicine.symptom, idiopathic normal pressure hydrocephalus, 030217 neurology & neurosurgery, Biomarkers |
| الوصف: | Idiopathic normal pressure hydrocephalus (iNPH) is caused by the accumulation of cerebrospinal fluid (CSF) and is characterized by gait disturbance, urinary incontinence, and dementia. iNPH dementia is treatable by shunt operation; however, since the cognitive symptoms of iNPH are often similar to those of other dementias, including Alzheimer's disease (AD), accurate diagnosis of iNPH is difficult. To overcome this problem, the identification of novel diagnostic markers to distinguish iNPH and AD is warranted. Using comparative proteomic analysis of CSF from patients with iNPH and AD, protein tyrosine phosphatase receptor type Q (PTPRQ) was identified as a candidate biomarker protein for discriminating iNPH from AD. ELISA analysis indicated that the PTPRQ concentration in the CSF was significantly higher in patients with iNPH compared with those with AD. In addition, the PTPRQ concentration in the CSF of non-responders to shunt operation (SNRs) tended to be relatively lower compared with that in the responders. PTPRQ may be a useful biomarker for discriminating between patients with iNPH and AD, and may be a potential companion biomarker to identify SNRs among patients with iNPH. Additional large-scale analysis may aid in understanding the novel aspects of iNPH. |
| اللغة: | English |
| تدمد: | 1791-3004 1791-2997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5504421da18a362caa84b9a4dce57cd1Test http://europepmc.org/articles/PMC5547938Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5504421da18a362caa84b9a4dce57cd1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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