Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease
| العنوان: | Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease |
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| المؤلفون: | Tsukuru Umemura, Porntip Chaichompoo, Yasuko Harada, Yuka Tanaka, Kamonlak Leecharoenkiat, Saovaros Svasti, Suthat Fucharoen, Yasunobu Abe, Duncan R. Smith, Orawan Sarakul |
| المصدر: | Molecular Medicine Reports |
| بيانات النشر: | D.A. Spandidos, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Cancer Research, thalassemia, Adolescent, Thalassemia, microRNA-451, Biology, Biochemistry, Hemolysis, 03 medical and health sciences, 0302 clinical medicine, Reticulocyte, hemic and lymphatic diseases, Genetics, medicine, Humans, Erythropoiesis, Molecular Biology, plasma, Oncogene, microRNA, beta-Thalassemia, Articles, Middle Aged, medicine.disease, Molecular medicine, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Hemoglobin E, Immunology, Molecular Medicine, Biomarker (medicine), Female, Biomarkers |
| الوصف: | In Southeast Asia, particularly in Thailand, β0-thalassemia/hemoglobin E (HbE) disease is a common hereditary hematological disease. It is associated with pathophysiological processes, such as the intramedullary destruction of immature erythroid cells and peripheral hemolysis of mature red blood cells. MicroRNA (miR) sequences, which are short non-coding RNA that regulate gene expression in a suppressive manner, serve a crucial role in human erythropoiesis. In the present study, the plasma levels of the erythroid-expressed miRNAs, miR‑451 and miR‑155, were analyzed in 23 patients with β0-thalassemia/HbE and 16 control subjects. Reverse transcription‑quantitative polymerase chain reaction analysis revealed significantly higher levels of plasma miR‑451 and miR‑155 in β0‑thalassemia/HbE patients when compared to the control subjects. Notably, among the β0‑thalassemia/HbE patients, a significant increase in miR‑451 levels was detected in severe cases when compared with mild cases. The levels of plasma miR‑451 correlated with reticulocyte and platelet counts. The results suggest that increased plasma miR‑451 levels may be associated with the degree of hemolysis and accelerated erythropoiesis in β0‑thalassemia/HbE patients. In conclusion, miR‑451 may represent a relevant biomarker for pathological erythropoiesis associated with β0-thalassemia/HbE. |
| اللغة: | English |
| تدمد: | 1791-3004 1791-2997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43493578d46f66b5935c8708cb531472Test http://europepmc.org/articles/PMC5428399Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....43493578d46f66b5935c8708cb531472 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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