دورية أكاديمية
Systematic review of clozapine cardiotoxicity
| العنوان: | Systematic review of clozapine cardiotoxicity |
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| المؤلفون: | Curto, Martina, Girardi, Nicoletta, Lionetto, Luana, Ciavarella, Giuseppino M., Ferracuti, Stefano, Baldessarini, Ross J. |
| المساهمون: | Curto, Martina, Girardi, Nicoletta, Lionetto, Luana, Ciavarella, Giuseppino M., Ferracuti, Stefano, Baldessarini, Ross J. |
| بيانات النشر: | Current Medicine Group LLC 1 |
| سنة النشر: | 2016 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Adverse, cardiac, clozapine, myocarditi, prevention, toxicity, adverse drug reaction reporting system, antipsychotic agent, cardiotoxicity, drug monitoring, human, psychotic disorder, cardiomyopathie, psychiatry and mental health |
| الوصف: | Clozapine is exceptionally effective in psychotic disorders and can reduce suicidal risk. Nevertheless, its use is limited due to potentially life-threatening adverse effects, including myocarditis and cardiomyopathy. Given their clinical importance, we systematically reviewed research on adverse cardiac effects of clozapine, aiming to improve estimates of their incidence, summarize features supporting their diagnosis, and evaluate proposed monitoring procedures. Incidence of early (≤2 months) myocarditis ranges from <0.1 to 1.0 % and later (3–12 months) cardiomyopathy about 10 times less. Diagnosis rests on relatively nonspecific symptoms, ECG changes, elevated indices of myocardial damage, cardiac MRI findings, and importantly, echocardiographic evidence of developing ventricular failure. Treatment involves stopping clozapine and empirical applications of steroids,diuretics, beta-blockers, and antiangiotensin agents. Mortality averages approximately 25 %. Safety of clozapine reuse remains uncertain. Systematic studies are needed to improve knowledge of the epidemiology, avoidance, early identification, and treatment of these adverse effects,with effective and practicable monitoring protocols. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27222142; info:eu-repo/semantics/altIdentifier/wos/WOS:000378862900007; volume:18; issue:7; firstpage:68; journal:CURRENT PSYCHIATRY REPORTS; http://hdl.handle.net/11573/1022115Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84971631306; http://www.springerlink.com/content/1523-3812Test/ |
| DOI: | 10.1007/s11920-016-0704-3 |
| الإتاحة: | https://doi.org/10.1007/s11920-016-0704-3Test http://hdl.handle.net/11573/1022115Test http://www.springerlink.com/content/1523-3812Test/ |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.7AF6F732 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11920-016-0704-3 |
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