Chondromas are benign cartilaginous tumours that rarely occur in the head and neck region. Only a limited number of cases have been reported involving the nasal septum. Here we report a case of a 55-year-old male that presented with a suspicious lesion involving his nasal septum and columella. The lesion was removed under general anesthestic using a combination of both columellar and hemitransfixion incisions. The lesion consisted of firm tan-white tissue measuring 2.5 cm. Histopathologic examination revealed a low-grade chondroid neoplasm with lobulated hyaline cartilage. No signs of ischemic change, significant pleomorphism, mitoses, or necrosis were present. This was consistent with the features of a chondroma rather than a low-grade chondrosarcoma. A chondroma should be considered in the differential diagnosis of nasal septum lesions. Surgical excision of the tumour is the preferred treatment option.
