دورية أكاديمية
In Vivo MR Imaging of Tumor-Associated Macrophages: The Next Frontier in Cancer Imaging
| العنوان: | In Vivo MR Imaging of Tumor-Associated Macrophages: The Next Frontier in Cancer Imaging |
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| المؤلفون: | Yang, Runze, Sarkar, Susobhan, Yong, Voon Wee E., Dunn, Jeff F. |
| بيانات النشر: | SAGE Publications Radiology Cumming School of Medicine //www.sherpa.ac.uk/romeo/issn/1178-623X/ |
| سنة النشر: | 2018 |
| المجموعة: | PRISM - University of Calgary Digital Repository |
| مصطلحات موضوعية: | Tumor-associated macrophage, cancer, imaging, cell tracking, magnetic resonance imaging |
| الوصف: | There is a complex interaction between cancer and the immune system. Tumor-associated macrophages (TAMs) can be subverted by the cancer to adopt a pro-tumor phenotype to aid tumor growth. These anti-inflammatory, pro-tumor TAMs have been shown to contribute to a worsened outcome in several different types of cancer. Various strategies aimed at combating the pro-tumor TAMs have been developed. Several therapies, such as oncolytic viral therapy and high-intensity focused ultrasound, have been shown to stimulate TAMs and suppress tumor growth. Targeting TAMs is a promising way to combat cancer, but sensitive imaging methods that are capable of detecting these therapeutic responses are needed. A promising idea is to use imaging contrast agents to label TAMs to determine their relative number and location within, and around the tumor. This can provide information about the efficacy of TAM depletion therapies, as well as macrophage-stimulating therapies. In this review, we describe various in vivo MRI methods capable of tracking TAMs, and conclude with a short section on tracking TAMs in patients. ; Alberta Innovates - Research Grant ; Alberta Cancer Foundation - Research Grant ; Brain Canada - Research Grant |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1178-623X |
| العلاقة: | http://dx.doi.org/10.11575/PRISM/33895Test; http://hdl.handle.net/1880/108914Test |
| DOI: | 10.1177/1178623X18771974 |
| DOI: | 10.11575/PRISM/33895 |
| الإتاحة: | https://doi.org/10.1177/1178623X18771974Test https://doi.org/10.11575/PRISM/33895Test http://hdl.handle.net/1880/108914Test |
| حقوق: | https://creativecommons.org/licenses/by-nc/4.0Test |
| رقم الانضمام: | edsbas.FBBEDC0A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1178623X |
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| DOI: | 10.1177/1178623X18771974 |