دورية أكاديمية
Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients
| العنوان: | Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients |
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| المؤلفون: | Simachew, Yonas Mulat, Antonić, Tamara, Gojković, Tamara, Vladimirov, Sandra, Mihajlović, Marija, Vujčić, Sanja, Miloševski-Lomić, Gordana, Vekić, Jelena, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Paripović, Dušan, Stefanović, Aleksandra |
| المصدر: | Biochemia Medica |
| بيانات النشر: | Croatian Society of Medical Biochemistry and Laboratory Medicine |
| سنة النشر: | 2022 |
| المجموعة: | FarFaR - Pharmacy Repository (Univ. of Belgrade, Fac. of Pharmacy) |
| مصطلحات موضوعية: | glucocorticoid therapy, non-cholesterol sterols, paediatric nephrotic syndrome, serum lipid profile |
| الوصف: | Introduction The aim of this study was to investigate lipoprotein particle distributions and the likelihood of achieving cholesterol homeostasis in the remission phase of nephrotic syndrome (NS) in paediatric patients. We hypothesized that lipoprotein particle distributions moved toward less atherogenic profile and that cholesterol homeostasis was achieved. Materials and methods Thirty-three children, 2 to 9 years old with NS were recruited. Blood sampling took place both in the acute phase and during remission. Serum low-density lipoprotein particles (LDL) and high-density lipoprotein particles (HDL) were separated using non-denaturing polyacrylamide gradient gel (3-31%) electrophoresis. Serum non-cholesterols sterols (NCSs), desmosterol, lathosterol, 7-dehydrocholesterol (7-DHC), campesterol and β-sitosterol were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Results All patients had desirable serum HDL cholesterol concentrations during remission. The dominant lipoprotein diameters and LDL subclass distribution did not change significantly during follow-up. In contrast, HDL lipoprotein particle distribution shifted towards larger particles. The absolute concentration of desmosterol was significantly lower during remission (P = 0.023). β-sitosterol concentration markedly increased during remission (P = 0.005). Desmosterol/β-sitosterol (P < 0.001) and 7-DHC/β-sitosterol (P = 0.005) ratios significantly declined during disease remission. Conclusions Favourable changes in the serum lipid profiles, HDL particle subclass distribution and cholesterol metabolism in paediatric patients with NS during remission took place. For the first time, we found that cholesterol homeostasis changed in favour of increased cholesterol absorption during disease remission. Nevertheless, complete cholesterol homeostasis was not achieved during disease remission. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1330-0962 |
| العلاقة: | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//; https://farfar.pharmacy.bg.ac.rs/handle/123456789/4195Test; 000820264100008; 2-s2.0-85133633842; http://farfar.pharmacy.bg.ac.rs/bitstream/id/9945/bitstream_9945.pdfTest |
| DOI: | 10.11613/BM.2022.020706 |
| الإتاحة: | https://doi.org/10.11613/BM.2022.020706Test https://farfar.pharmacy.bg.ac.rs/handle/123456789/4195Test http://farfar.pharmacy.bg.ac.rs/bitstream/id/9945/bitstream_9945.pdfTest |
| حقوق: | openAccess ; https://creativecommons.org/licenses/by/4.0Test/ ; BY |
| رقم الانضمام: | edsbas.D01AF2FA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13300962 |
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| DOI: | 10.11613/BM.2022.020706 |