Nearly one in four deaths in the United States and Europe are due to cancer (American Cancer Society, 2009; Jemal et al., 2011). Despite the continued high death rate due to cancer, great advances made in the treatment of cancerCONTENTS9.1 Introduction 269 9.1.1 Cancer, Society, and Role of Imaging 269 9.1.2 Biology of Tumors 2709.2 MR 1H Relaxometry Characteristics of Tumors 271 9.3 Novel 1H Contrast Mechanisms for Imaging Tumors 2749.3.1 Diffusion 274 9.3.2 Dynamic Contrast-Enhanced MRI 286 9.3.3 Other Vascular Applications 2989.4 Non-1H Contrast Mechanisms for Imaging Tumors 300 9.4.1 31P Spectroscopy, 23Na Imaging, 13C and DynamicNuclear Polarization 300 9.5 Morphometric Analysis 302
