التفاصيل البيبلوغرافية
| العنوان: |
COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease |
| المؤلفون: |
Lowe, Katherine E., Regan, Elizabeth A., Anzueto, Antonio, Austin, Erin, Austin, John H. M., Beaty, Terri H., Benos, Panayiotis V., Benway, Christopher J., Bhatt, Surya P., Bleecker, Eugene R., Bodduluri, Sandeep, Bon, Jessica, Boriek, Aladin M., Boueiz, Adel RE., Bowler, Russell P., Budoff, Matthew, Casaburi, Richard, Castaldi, Peter J., Charbonnier, Jean-Paul, Cho, Michael H., Comellas, Alejandro, Conrad, Douglas, Costa Davis, Corinne, Criner, Gerard J., Curran-Everett, Douglas, Curtis, Jeffrey L., DeMeo, Dawn L., Diaz, Alejandro A., Dransfield, Mark T., Dy, Jennifer G., Fawzy, Ashraf, Fleming, Margaret, Flenaugh, Eric L., Foreman, Marilyn G., Fortis, Spyridon, Gebrekristos, Hirut, Grant, Sarah, Grenier, Philippe A., Gu, Tian, Gupta, Abhya, Han, MeiLan K., Hanania, Nicola A., Hansel, Nadia N., Hayden, Lystra P., Hersh, Craig P., Hobbs, Brian D., Hoffman, Eric A., Hogg, James C., Hokanson, John E., Hoth, Karin F. |
| بيانات النشر: |
COPD Foundation Inc |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
Original Research, envir, psy |
| الوصف: |
Background: Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified a substantial number of individuals without spirometric evidence of COPD who suffer from respiratory symptoms and/or increased morbidity and mortality. There is a clear need for an expanded definition of COPD that is linked to physiologic, structural (computed tomography [CT]) and clinical evidence of disease. Using data from the COPD Genetic Epidemiology study (COPDGene(®)), we hypothesized that an integrated approach that includes environmental exposure, clinical symptoms, chest CT imaging and spirometry better defines disease and captures the likelihood of progression of respiratory obstruction and mortality. Methods: Four key disease characteristics – environmental exposure (cigarette smoking), clinical symptoms (dyspnea and/or chronic bronchitis), chest CT imaging abnormalities (emphysema, gas trapping and/or airway wall thickening), and abnormal spirometry – were evaluated in a group of 8784 current and former smokers who were participants in COPDGene(®) Phase 1. Using these 4 disease characteristics, 8 categories of participants were identified and evaluated for odds of spirometric disease progression (FEV(1) > 350 ml loss over 5 years), and the hazard ratio for all-cause mortality was examined. Results: Using smokers without symptoms, CT imaging abnormalities or airflow obstruction as the reference population, individuals were classified as Possible COPD, Probable COPD and Definite COPD. Current Global initiative for obstructive Lung Disease (GOLD) criteria would diagnose 4062 (46%) of the 8784 study participants with COPD. The proposed COPDGene(®) 2019 diagnostic criteria would add an additional 3144 participants. Under the new criteria, 82% of the 8784 study participants would be diagnosed with Possible, Probable or Definite COPD. These COPD groups showed increased risk of . |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| العلاقة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020846Test/ |
| الإتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020846Test/ |
| حقوق: |
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| رقم الانضمام: |
edsbas.83369C21 |
| قاعدة البيانات: |
BASE |
