دورية أكاديمية
Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder: A Multi-Institutional Korean Study
| العنوان: | Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder: A Multi-Institutional Korean Study |
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| المساهمون: | College of Medicine, Dept. of Pathology, Sanghui Park, So Young Kang, Ghee Young Kwon, Ji Eun Kwon, Sang Kyum Kim, Ji Yeon Kim, Chul Hwan Kim, Hyun-Jung Kim, Kyung Chul Moon, Ju Yeon Pyo, Won Young Park, Eun Su Park, Ji-Youn Sung, Sun Hee Sung, Young-Ha Oh, Seung Eun Lee, Wonae Lee, Jong Im Lee, Nam Hoon Cho, Soo Jin Jung, Min-Sun Cho, Yong Mee Cho, Hyun Yee Cho, Eun Jung Cha, Yang-Seok Chae, Gheeyoung Choe, Yeong Jin Choi, Jooryung Huh, Jae Y. Ro, Kim, Sang Kyum, Cho, Nam Hoon |
| بيانات النشر: | College of American Pathologists |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Aged, DNA Mutational Analysis, Female, Humans, Immunohistochemistry, Male, Middle Aged, Mutation, Paraganglioma/enzymology, Paraganglioma/genetics, Paraganglioma/pathology, Retrospective Studies, Succinate Dehydrogenase/genetics, Succinate Dehydrogenase/metabolism, Urinary Bladder/enzymology, Urinary Bladder/pathology, Urinary Bladder Neoplasms/enzymology, Urinary Bladder Neoplasms/genetics, Urinary Bladder Neoplasms/pathology, Young Adult |
| الوصف: | CONTEXT: Because of the limited number of available primary bladder paraganglioma (PBPG) cases, the rates of succinate dehydrogenase (SDH) mutations and the clinicopathologic characteristics of SDH-deficient tumors have not been fully studied. OBJECTIVE: To define the clinicopathologic and molecular characteristics of PBPGs. DESIGN: A total of 52 PBPGs were collected retrospectively. SDHA and SDHB immunohistochemical stains were performed. In cases of SDHB expression loss, mutation analyses of SDHB, SDHC, and SDHD were performed. RESULTS: The clinicopathologic features were analyzed for 52 cases (M:F = 27:25), with a mean age of 56 years (range, 22-79 years). Tumor sizes were 0.5 to 8 cm (mean, 2.4 cm). Tumor necrosis was present in 5 of 52 cases (10%), involvement of muscularis propria in 41 (79%), and lymphovascular tumor invasion in 6 (12%). During a mean follow-up period of 41 months (range, 1-161 months), 3 of 52 patients (6%) developed metastases, but no one died from the disease. Immunohistochemistry for SDHA and SDHB showed that all cases were SDHA intact. Among them, 43 cases had intact SDHB, whereas 9 cases were SDHB deficient. Compared with the SDHB-intact cases, the SDHB-deficient cases were characterized by large tumor sizes (4.5 versus 1.9 cm; P < .001), a higher number of mitoses per 10 high-powered fields (2.6 versus 0.1; P = .002), and frequent lymphovascular tumor invasion (33% versus 7%; P = .02) and metastases (22% versus 2%; P = .02). Mutational analyses for SDHB, SDHC, and SDHD were performed in 9 SDHB-deficient cases. Among them, 6 cases were successfully sequenced and revealed SDHB mutations only. CONCLUSIONS: Large tumor size, a higher number of mitoses, and the presence of lymphovascular tumor invasion and SDHB mutations suggest malignant paraganglioma. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0003-9985 1543-2165 |
| العلاقة: | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE; J00228; OAK-2017-07531; https://ir.ymlib.yonsei.ac.kr/handle/22282913/161634Test; T201705348; ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, Vol.141(5) : 671-677, 2017 |
| DOI: | 10.5858/arpa.2016-0403-OA |
| الإتاحة: | https://doi.org/10.5858/arpa.2016-0403-OATest https://ir.ymlib.yonsei.ac.kr/handle/22282913/161634Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.E7A45485 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00039985 15432165 |
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| DOI: | 10.5858/arpa.2016-0403-OA |