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“Kankasha” in Kassala: a prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan

التفاصيل البيبلوغرافية
العنوان: “Kankasha” in Kassala: a prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan
المؤلفون: Bower, Hilary, Karsany, Mubarak el, Adam Hussein, Abd Alhadi, Idriss, Mubarak Ibrahim, AlZain, Ma’aaza Abasher, Ahmed Alfakiyousif, Mohamed Elamin, Mohamed, Rehab, Mahmoud, Iman, Albadri, Omer, Alnour Mahmoud, Suha Abdulaziz, Abdalla, Orwa Ibrahim, Eldigail, Mawahib, Elagib, Nuha, Arnold, Ulrike, Gutierrez, Bernardo, Pybus, Oliver G, Carter, Daniel P, Pullan, Steven T, Jacob, Shevin T, Abdallah, Tajeldin Mohammedein, Gannon, Benedict, Fletcher, Tom E
بيانات النشر: Cold Spring Harbor Laboratory
سنة النشر: 2020
المجموعة: London School of Hygiene & Tropical Medicine: LSHTM Research Online
الوصف: AbstractBackgroundThe public health impact of Chikungunya virus (CHIKV) is often underestimated. Usually considered a mild condition of short duration, recent outbreaks have reported greater incidence of severe illness, fatality, and longer-term disability. In 2018/19, Eastern Sudan experienced the largest epidemic of CHIKV in Africa to date, affecting an estimated 487,600 people. Known locally as Kankasha, this study examines the clinical characteristics, risk factors, and phylogenetics of the CHIKV epidemic in Kassala City.Methodology/Principal FindingsA prospective cohort of 142 cases (102 adults, 40 children) were enrolled at Kassala Teaching Hospital in October 2018. Clinical information, socio-demographic data and sera samples were analysed to confirm diagnosis, characterise illness, and identify the viral strain. CHIKV infection was confirmed by real-time reverse transcription-PCR in 84.5% (120/142) of participants. Nine had concurrent CHIKV/Dengue virus (DENV) infection and 28.8% had a positive Rapid Diagnostic Test for malaria. Five percent had haemorrhagic symptoms including two children with life-threatening haemorrhage. One CHIKV-positive participant died with acute renal injury.Ninety to 120 days post-illness, 63% of those followed-up were still experiencing arthralgia in one or more joints, and 11% remained moderately disabled using Rapid3 assessment. Phylogenetic analysis showed all CHIKV infections belonged to a single clade within the Indian Ocean Lineage (IOL) of the East/Central/South African (ECSA) genotype. History of contact with an infected person was the only socio-demographic factor associated with infection (p=0.01), suggesting that vector transmission in households is ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: text
اللغة: English
العلاقة: https://researchonline.lshtm.ac.uk/id/eprint/4662195/1/Kankasha%20in%20Kassala%2030%20April%202021.pdfTest; Bower, Hilary ; Karsany, Mubarak el; Adam Hussein, Abd Alhadi; Idriss, Mubarak Ibrahim; AlZain, Ma’aaza Abasher; Ahmed Alfakiyousif, Mohamed Elamin; Mohamed, Rehab; Mahmoud, Iman; Albadri, Omer; Alnour Mahmoud, Suha Abdulaziz; +12 more. Abdalla, Orwa Ibrahim; Eldigail, Mawahib; Elagib, Nuha; Arnold, Ulrike; Gutierrez, Bernardo; Pybus, Oliver G; Carter, Daniel P; Pullan, Steven T; Jacob, Shevin T; Abdallah, Tajeldin Mohammedein; Gannon, Benedict; Fletcher, Tom E; (2020) “Kankasha” in Kassala: a prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan. BMJ Yale - preprint. DOI: https://doi.org/10.1101/2020.09.23.20199976Test
الإتاحة: https://doi.org/10.1101/2020.09.23.20199976Test
https://researchonline.lshtm.ac.uk/id/eprint/4662195Test/
https://researchonline.lshtm.ac.uk/id/eprint/4662195/1/Kankasha%20in%20Kassala%2030%20April%202021.pdfTest
حقوق: cc_by
رقم الانضمام: edsbas.7ECE777E
قاعدة البيانات: BASE
الوصف
الوصف غير متاح.