Results of interferon-based treatments in Alaska Native and American Indian population with chronic hepatitis C
| العنوان: | Results of interferon-based treatments in Alaska Native and American Indian population with chronic hepatitis C |
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| المؤلفون: | Chriss Homan, Philip R. Spradling, Stephen Livingston, Brian J. McMahon, Lisa Townshend-Bulson, Dana J. T. Bruden, Brenna C. Simons, James E. Gove, Julia Plotnik |
| المساهمون: | Centers for Disease Control and Prevention |
| المصدر: | International Journal of Circumpolar Health; Vol 75 (2016) International Journal of Circumpolar Health International Journal of Circumpolar Health, Vol 75, Iss 0, Pp 1-8 (2016) |
| بيانات النشر: | Co-Action Publishing, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Health (social science), Epidemiology, Hepacivirus, medicine.disease_cause, Gastroenterology, Polyethylene Glycols, Telaprevir, chemistry.chemical_compound, Pegylated interferon, discontinuation, indigenous population, longitudinal study, sustained virologic response, 0302 clinical medicine, Pegylated interferon, Interferon, Original Research Article, Longitudinal Studies, 030212 general & internal medicine, education.field_of_study, sustained virologic response, longitudinal study, virus diseases, General Medicine, Middle Aged, Alaskan Natives, Recombinant Proteins, 3. Good health, Treatment Outcome, Drug Therapy, Combination, Female, 030211 gastroenterology & hepatology, medicine.drug, Adult, medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, clinical investigation, infectious disease, lcsh:RC955-962, Hepatitis C virus, Population, Alpha interferon, viral hepatitis, Antiviral Agents, Risk Assessment, 03 medical and health sciences, Boceprevir, Internal medicine, Ribavirin, medicine, Humans, pegylated interferon, education, Aged, business.industry, Public Health, Environmental and Occupational Health, Interferon-alpha, Hepatitis C, Chronic, indigenous population, digestive system diseases, chemistry, Immunology, Indians, North American, business, Alaska, discontinuation, Follow-Up Studies |
| الوصف: | Background . There have been few reports of hepatitis C virus (HCV) treatment results with interferon-based regimens in indigenous populations. Objective . To determine interferon-based treatment outcome among Alaska Native and American Indian (AN/AI) population. Design . In an outcomes study of 1,379 AN/AI persons with chronic HCV infection from 1995 through 2013, we examined treatment results of 189 persons treated with standard interferon, interferon plus ribavirin, pegylated interferon plus ribavirin and triple therapy with a protease inhibitor. For individuals treated with pegylated interferon and ribavirin, the effect of patient characteristics on response was also examined. Results . Sustained virologic response (SVR) with standard interferon was 16.7% (3/18) and with standard interferon and ribavirin was 29.7% (11/37). Of 119 persons treated with pegylated interferon and ribavirin, 61 achieved SVR (51.3%), including 10 of 46 with genotype 1 (21.7%), 38 of 51 with genotype 2 (74.5%) and 13 of 22 with genotype 3 (59.1%). By multivariate analysis, SVR in the pegylated interferon group was associated with female sex (p=0.002), estimated duration of infection (p=0.034) and HCV genotype (p |
| وصف الملف: | application/pdf; text/html; application/epub+zip; application/xml |
| اللغة: | English |
| تدمد: | 1239-9736 1797-237X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022dccf02aa83a6629b95c2c834e1ad9Test http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/30696Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....022dccf02aa83a6629b95c2c834e1ad9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12399736 1797237X |
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