Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children
| العنوان: | Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children |
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| المؤلفون: | Qiong Zhang, Alberto M. Soares, Richard L. Guerrant, Rosa Maria Salani Mota, Aldo A. M. Lima, Ítalo L Figueiredo, Gregory M. Anstead, Reinaldo B. Oriá, Noélia L. Lima |
| المصدر: | Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC Clinics, Vol 69, Iss 4, Pp 225-233 (2014) Clinics, Volume: 69, Issue: 4, Pages: 225-233, Published: APR 2014 Clinics Clinics; v. 69 n. 4 (2014); 225-233 Clinics; Vol. 69 Núm. 4 (2014); 225-233 Clinics; Vol. 69 No. 4 (2014); 225-233 Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Clinics, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Glutamina, Arginine, Glutamine, Hormonal Biomarkers, Lactulose, chemistry.chemical_compound, Intestinal mucosa, Poverty Areas, Micronutrients, Insulin-Like Growth Factor I, Intestinal Mucosa, Child, Vitamin A, 2. Zero hunger, lcsh:R5-920, Anthropometry, Leptin, Vitamins, General Medicine, Clinical Science, Micronutrient, Intestinal Barrier Function, 3. Good health, Drug Combinations, Zinc, Treatment Outcome, Child, Preschool, Female, Growth and Development, lcsh:Medicine (General), Brazil, medicine.drug, Vitamin, Vitamina A, medicine.medical_specialty, Adolescent, Biology, Stress, Double-Blind Method, Stress, Physiological, Internal medicine, medicine, Humans, Adiponectin, Malnutrition, Infant, Hormones, Endocrinology, chemistry, Dietary Supplements, Micronutrientes |
| الوصف: | OBJECTIVE: To determine the impact of supplemental zinc, vitamin A, and glutamine alone or in combination on growth, intestinal barrier function, stress and satiety-related hormones among Brazilian shantytown children with low median height-for-age z-scores. METHODS: A randomized, double-blind, placebo-controlled trial was conducted in children aged two months to nine years from the urban shanty compound community of Fortaleza, Brazil. Demographic and anthropometric information was assessed. The random treatment groups available for testing (a total of 120 children) were as follows: (1) glutamine alone, n = 38; (2) glutamine plus vitamin A plus zinc, n = 37; and a placebo (zinc plus vitamin A vehicle) plus glycine (isonitrogenous to glutamine) control treatment, n = 38. Leptin, adiponectin, insulin-like growth factor (IGF-1), and plasma levels of cortisol were measured with immune-enzymatic assays; urinary lactulose/mannitol and serum amino acids were measured with high-performance liquid chromatography. ClinicalTrials.gov: NCT00133406. RESULTS: Glutamine treatment significantly improved weight-for-height z-scores compared to the placebo-glycine control treatment. Either glutamine alone or all nutrients combined prevented disruption of the intestinal barrier function, as measured by the percentage of lactulose urinary excretion and the lactulose:mannitol absorption ratio. Plasma leptin was negatively correlated with plasma glutamine (p = 0.002) and arginine (p = 0.001) levels at baseline. After glutamine treatment, leptin was correlated with weight-for-age (WAZ) and weight-for-height z-scores (WHZ) (p≤0.002) at a 4-month follow-up. In addition, glutamine and all combined nutrients (glutamine, vitamin A, and zinc) improved the intestinal barrier function in these children. CONCLUSION: Taken together, these findings reveal the benefits of glutamine alone or in combination with other gut-trophic nutrients in growing children via interactions with leptin. |
| وصف الملف: | text/html; application/pdf |
| اللغة: | English |
| تدمد: | 1980-5322 1807-5932 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd649b009f6fe8b5b8d7df503f936a38Test http://www.repositorio.ufc.br/handle/riufc/9419Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bd649b009f6fe8b5b8d7df503f936a38 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19805322 18075932 |
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