دورية أكاديمية
Prognostic model for advanced breast carcinoma with luminal subtype and impact of hormonal maintenance: Implications for post-progression and conditional survival
| العنوان: | Prognostic model for advanced breast carcinoma with luminal subtype and impact of hormonal maintenance: Implications for post-progression and conditional survival |
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| المؤلفون: | Tortora G., Bria E. |
| المساهمون: | Carbognin, L., Sperduti, I., Ciccarese, M., Fabi, A., Petrucelli, L., Vari, S., Forcignano, R. C., Nortilli, R., Vicentini, C., Pilotto, S., Merler, S., Zampiva, I., Brunelli, M., Manfrin, E., Giannarelli, D., Tortora, Giampaolo, Bria, Emilio |
| بيانات النشر: | Churchill Livingstone |
| سنة النشر: | 2016 |
| المجموعة: | Università Cattolica del Sacro Cuore: PubliCatt |
| مصطلحات موضوعية: | Advanced breast, Breast cancer, Luminal, Prognosi, Adult, Aged, 80 and over, Antineoplastic Agents, Hormonal, Breast Neoplasm, Disease Progression, Disease-Free Survival, Female, Human, Maintenance Chemotherapy, Middle Aged, Multivariate Analysi, Propensity Score, Proportional Hazards Model, Retrospective Studie, Risk Assessment, Survival Analysi, Nomograms, Settore MED/06 - ONCOLOGIA MEDICA |
| الوصف: | Background: The aim of this analysis was to develop and validate a prognostic model for advanced breast cancer (ABC) with luminal subtype based on the combination of clinical, pathological and therapeutic predictors to provide a practical tool to evaluate patients' prognosis. Methods: Clinical and pathological data were retrospectively correlated to progression-free and overall survival (PFS/OS) using a Cox model. Significant treatment variables were adjusted with the propensity score analysis. A continuous score to identify risk classes was derived according to model ratios. The performance of the risk-class model was tested for post-progression survival (PPS) and conditional survival (CS) as well. Results: Data from 335 patients (3 institutions) were gathered (median follow-up 58 months). At multivariate analysis Ki67, Performance Status (PS) and number of metastatic sites were significant predictors for PFS, whereas Ki67, PS, brain metastases, PFS after 1st-line therapy, number of chemotherapy lines, hormonal therapy and maintenance were significant predictors for OS. The hormonal maintenance resulted to be prognostic after adjustment with propensity score analysis. A two-class model significantly differentiated low-risk and high-risk patients for 2-year PFS (31.5% and 11.0%, p < 0.0001), and 3-years OS (57.1% and 4.8%, p < 0.0001). A three-class model separated low risk, intermediate-risk, and high-risk patients for 2-year PFS (40.8%, 24.4%, and 11.0%, p < 0.0001) and 3-year OS (68.1%, 24.8%, and 4.8%, p < 0.0001). Both models equally discriminate the luminal ABC prognosis in terms of PPS and CS. Conclusions: A risk stratification model including 'easy-to-obtain' clinical, pathological and therapeutic parameters accurately separates luminal ABC patients into different risk classes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27394675; info:eu-repo/semantics/altIdentifier/wos/WOS:000383822000004; volume:29; issue:ottobre; firstpage:24; lastpage:30; numberofpages:7; issueyear:2016; journal:THE BREAST; http://hdl.handle.net/10807/153609Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84977470344 |
| DOI: | 10.1016/j.breast.2016.06.021 |
| الإتاحة: | https://doi.org/10.1016/j.breast.2016.06.021Test http://hdl.handle.net/10807/153609Test |
| رقم الانضمام: | edsbas.1A0AFD4C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.breast.2016.06.021 |
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