دورية أكاديمية
Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study
| العنوان: | Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study |
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| المؤلفون: | Delvin, E., Alos, N., Rauch, F., Marcil, V., Morel, S., Boisvert, M., Lecours, M.-A., Laverdière, C., Sinnett, D., Krajinovic, M., Dubois, J., Drouin, S., Lefebvre, G., Samoilenko, M., Nyalendo, C., Cavalier, Etienne, Levy, Etienne |
| المصدر: | Clinical Nutrition (2019) |
| بيانات النشر: | Churchill Livingstone |
| سنة النشر: | 2019 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Acute lymphoblastic leukemia, Bone formation, Bone resorption, CTX, P1NP, Human health sciences, Laboratory medicine & medical technology, Pediatrics, Sciences de la santé humaine, Médecine de laboratoire & technologie médicale, Pédiatrie |
| الوصف: | peer reviewed ; Background: The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood. Objective: This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors. Results: Food frequency questionnaires reveal that (i) the total vitamin D intake varies greatly (44–2132 IU/d), (ii) only 16.8% of the participants consume vitamin D supplements, and (iii) 74% of survivors' intakes are below the Recommended Daily Intakes (400 IU/d). For the 42 participants taking vitamin D supplements, the median (2.5–97.5%iles) intake is 600 IU/d (21.2–1972 IU/d). Sixteen participants are vitamin D deficient (<30 nM) and 66 insufficient (≥30 – <50 nM). Serum 24,25(OH)2D3 concentrations are directly related to those of 25OHD3, and those of 3-epi-25OHD3 below the Lower Limit of Quantification in most samples. The participants' serum concentrations of cross-linked C-telopeptide of type-I collagen and intact amino-terminal pro-peptide of type-I collagen decrease steadily with age, leveling at adulthood, and are at all times higher in males. Conclusion: The present study shows that the prevalence of vitamin D insufficiency or deficiency is not greater in cALL survivors compared to the general Canadian population despite low vitamin D food and supplement intakes. Furthermore, there seem to be no overt imbalance in the gender- and age-adjusted serum bone turnover marker concentrations. © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0261-5614 1532-1983 |
| العلاقة: | urn:issn:0261-5614; urn:issn:1532-1983; https://orbi.uliege.be/handle/2268/228406Test; info:hdl:2268/228406; scopus-id:2-s2.0-85042682640; info:pmid:29503055 |
| DOI: | 10.1016/j.clnu.2018.02.006 |
| الإتاحة: | https://doi.org/10.1016/j.clnu.2018.02.006Test https://orbi.uliege.be/handle/2268/228406Test |
| حقوق: | restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.BC5B01EA |
| قاعدة البيانات: | BASE |
| تدمد: | 02615614 15321983 |
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| DOI: | 10.1016/j.clnu.2018.02.006 |