دورية أكاديمية
Diagnosis of persistent ovarian carcinoma with three-step immunoscintigraphy
| العنوان: | Diagnosis of persistent ovarian carcinoma with three-step immunoscintigraphy |
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| المؤلفون: | Magnani, P, Grana, C, Songini, C, Frigerio, L, Pecorelli, S, Mangili, G, Mariani, CD, Paganelli, G., FAZIO, FERRUCCIO, COLOMBO, NICOLETTA |
| المساهمون: | Magnani, P, Fazio, F, Grana, C, Songini, C, Frigerio, L, Pecorelli, S, Mangili, G, Colombo, N, Mariani, C, Paganelli, G |
| بيانات النشر: | Churchill Livingstone |
| سنة النشر: | 2000 |
| المجموعة: | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| مصطلحات موضوعية: | Radioimmunodetection, Recurrence, Ovarian Neoplasm, Middle Aged, CA-125 Antigen, Female, Aged, Adult, Humans, MED/40 - GINECOLOGIA E OSTETRICIA |
| الوصف: | The diagnosis of recurrent ovarian carcinoma is usually determined at surgical re-exploration since the main non-invasive diagnostic tests have low accuracy. It would be desirable to have a high accuracy non-invasive diagnostic procedure. With this aim, we have assessed the utility of three-step immunoscintigraphy. Thirty patients were intravenously injected with biotinylated monoclonal antibodies MOv18 and B72.3, followed by avidin-streptavidin injection and finally by 111In-biotin. Tumour recurrences were imaged 2 h post radioactivity injection. All patients underwent surgical re-exploration 3-4 days after immunoscintigraphy; the presence of tumour in the area of immunoscintigraphic uptake was evaluated in the biopsied material. Twenty-one patients studied were true-positive, five were true-negative, four were false-positive and none was false-negative. The diagnostic accuracy, positive predictive value and negative predictive value were 87%, 84% and 100% respectively. If these findings are confirmed in a larger number of patients, we expect immunoscintigraphy to be introduced as a cost-effective procedure in the follow-up of patients who have received surgery for ovarian carcinoma, since it promises to reliably identify patients who do not require surgical re-exploration, and guide biopsies when they are indicated. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/10682674; info:eu-repo/semantics/altIdentifier/wos/WOS:000085031700019; volume:82; issue:3; firstpage:616; lastpage:620; numberofpages:5; journal:BRITISH JOURNAL OF CANCER; http://hdl.handle.net/10281/27677Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033968017 |
| DOI: | 10.1054/bjoc.1999.0972 |
| الإتاحة: | https://doi.org/10.1054/bjoc.1999.0972Test http://hdl.handle.net/10281/27677Test |
| رقم الانضمام: | edsbas.5571D0BE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1054/bjoc.1999.0972 |
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