Impact of multi-micronutrient supplementation on lipidemia of children and adolescents
| العنوان: | Impact of multi-micronutrient supplementation on lipidemia of children and adolescents |
|---|---|
| المؤلفون: | Nicolas Christinat, Jacqueline Pontes Monteiro, Anirikh Chakrabarti, Jim Kaput, Michael Eiden, Delphine Morin-Rivron, Mojgan Masoodi |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Chakrabarti, Anirikh; Eiden, Michael; Morin-Rivron, Delphine; Christinat, Nicolas; Monteiro, Jacqueline P; Kaput, Jim; Masoodi, Mojgan (2020). Impact of multi-micronutrient supplementation on lipidemia of children and adolescents. Clinical nutrition, 39(7), pp. 2211-2219. Elsevier 10.1016/j.clnu.2019.09.010 <http://dx.doi.org/10.1016/j.clnu.2019.09.010Test> |
| بيانات النشر: | CHURCHILL LIVINGSTONE |
| مصطلحات موضوعية: | Male, Proteomics, 0301 basic medicine, Time Factors, vitamin-a-deficiency, medicine.medical_treatment, Cholesterol, VLDL, alpha-Tocopherol, efficacy, cardiovascular-disease, SISTEMA CARDIOVASCULAR, Critical Care and Intensive Care Medicine, chemistry.chemical_compound, 0302 clinical medicine, prevention, 610 Medicine & health, Child, Vitamin A, Nutrition and Dietetics, Age Factors, cardiovascular health, Lipidome, Micronutrient, vitamins, Lipids, Treatment Outcome, Female, lipids (amino acids, peptides, and proteins), Brazil, Vitamin, lipidemia, medicine.medical_specialty, Adolescent, Hyperlipidemias, 030209 endocrinology & metabolism, 03 medical and health sciences, serum 25-hydroxyvitamin d, Internal medicine, medicine, Humans, cancer, Triglycerides, 030109 nutrition & dietetics, Triglyceride, business.industry, Cholesterol, Vitamin E, Lipid metabolism, womens health, lipoproteins, Endocrinology, chemistry, micronutrients, tocotrienol-rich fraction, Dietary Supplements, lipidomics, business, metabolism, Biomarkers, Lipoprotein |
| الوصف: | Background: Micronutrient supplementation has been extensively explored as a strategy to improve health and reduce risk of chronic diseases. Fat-soluble vitamins like A and E with their antioxidant properties and mechanistic interactions with lipoproteins, have potentially a key impact on lipid metabolism and lipidemia. Objective: The impact of micronutrients on lipid metabolism requires further investigation including characterization of plasma lipidome following supplementation and any cause-effect on circulating lipids. Design: In this study, we elucidate the effect and associations of a multi-micronutrient intervention in Brazilian children and teens with lipoprotein alterations and lipid metabolism. Results: Our analysis suggests a combination of short and long-term impact of supplementation on lipid metabolism, potentially mediated primarily by alpha-tocopherol (vitamin E) and retinol (vitamin A). Among the lipid classes, levels of phospholipids, lysophospholipids, and cholesterol esters were impacted the most along with differential incorporation of stearic, palmitic, oleic and arachidonic acids. Integrated analysis with proteomic data suggested potential links to supplementation-mediated alterations in protein levels of phospholipases and pyruvate dehydrogenase kinase 1 (PDK1). Conclusions: Associations between the observed differences in lipidemia, total triglyceride, and VLDL-cholesterol levels suggest that micronutrients may play a role in reducing these risk factors for cardiovascular disease in children. This would require further investigation. (C) 2019 The Author(s). Published by Elsevier Ltd. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2a228f6d98092d6ca5c87810993bfeTest https://infoscience.epfl.ch/record/286603Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ba2a228f6d98092d6ca5c87810993bfe |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |