Effects of Flavonoid Compounds on β-amyloid-peptide-induced Neuronal Death in Cultured Mouse Cortical Neurons
| العنوان: | Effects of Flavonoid Compounds on β-amyloid-peptide-induced Neuronal Death in Cultured Mouse Cortical Neurons |
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| المؤلفون: | Seong-Min Choi, Ki-Hyun Cho, Jong-Keun Kim, Yeun-Hee Cho, Jane Chang, Kang-Ho Choi, Myeong-Kyu Kim, Man-Seok Park, Byeong C. Kim |
| المصدر: | Chonnam Medical Journal |
| بيانات النشر: | Chonnam National University Medical School, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Flavonoids, business.industry, General Engineering, food and beverages, Alzheimer's disease, Pharmacology, Epigallocatechin gallate, Ascorbic acid, Neuroprotection, Baicalein, chemistry.chemical_compound, chemistry, Biochemistry, β-Amyloid peptide, Apigenin, Medicine, Original Article, heterocyclic compounds, Myricetin, business, Kaempferol, Luteolin, Neuroscience |
| الوصف: | Excessive accumulation of β-amyloid peptide (Aβ) is one of the major mechanisms responsible for neuronal death in Alzheimer's disease. Flavonoids, primarily antioxidants, are a group of polyphenolic compounds synthesized in plant cells. The present study aimed to identify flavonoid compounds that could inhibit Aβ-induced neuronal death by examining the effects of various flavonoids on the neurotoxicity of Aβ fragment 25-35 (Aβ25-35) in mouse cortical cultures. Aβ25-35 induced concentration- and exposure-time-dependent neuronal death. Neuronal death induced by 20 µM Aβ25-35 was significantly inhibited by treatment with either Trolox or ascorbic acid. Among 10 flavonoid compounds tested [apigenin, baicalein, catechin, epicatechin, epigallocatechin gallate (EGCG), kaempferol, luteolin, myricetin, quercetin, and rutin], all except apigenin showed strong 1,1-diphenyl-2-pycrylhydrazyl (DPPH) scavenging activity under cell-free conditions. The flavonoid compounds except apigenin at a concentration of 30 µM also significantly inhibited neuronal death induced by 20 µM Aβ25-35 at the end of 24 hours of exposure. Epicatechin, EGCG, luteolin, and myricetin showed more potent and persistent neuroprotective action than did the other compounds. These results demonstrated that oxidative stress was involved in Aβ-induced neuronal death, and antioxidative flavonoid compounds, especially epicatechin, EGCG, luteolin, and myricetin, could inhibit neuronal death. These findings suggest that these four compounds may be developed as neuroprotective agents against Alzheimer's disease. |
| تدمد: | 2233-7393 2233-7385 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36290a53af4b4169dc7543b0e71c5a4aTest https://doi.org/10.4068/cmj.2014.50.2.45Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....36290a53af4b4169dc7543b0e71c5a4a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22337393 22337385 |
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