دورية أكاديمية
Computational design of proteins with novel structure and functions
| العنوان: | Computational design of proteins with novel structure and functions |
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| المؤلفون: | Yang, Wei, Lai, Lu-Hua |
| المساهمون: | Lai, LH (reprint author), Peking Univ, BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China., Peking Univ, BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China., Peking Univ, Coll Chem & Mol Engn, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China., Peking Univ, Ctr Quantitat Biol, Beijing 100871, Peoples R China., Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China. |
| المصدر: | 知网 ; EI ; SCI |
| بيانات النشر: | CHINESE PHYSICS B |
| سنة النشر: | 2016 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | computational protein design, de novo protein design, enzyme design, protein-protein interaction, ATOMIC-LEVEL ACCURACY, HIGH-ACTIVITY MUTANTS, DE-NOVO DESIGN, ENERGY FUNCTIONS, SIDE-CHAIN, HUMAN BUTYRYLCHOLINESTERASE, BINDING-PROTEINS, 4-HELIX BUNDLE, FORCE-FIELD |
| الوصف: | Computational design of proteins is a relatively new field, where scientists search the enormous sequence space for sequences that can fold into desired structure and perform desired functions. With the computational approach, proteins can be designed, for example, as regulators of biological processes, novel enzymes, or as biotherapeutics. These approaches not only provide valuable information for understanding of sequence-structure-function relations in proteins, but also hold promise for applications to protein engineering and biomedical research. In this review, we briefly introduce the rationale for computational protein design, then summarize the recent progress in this field, including de novo protein design, enzyme design, and design of protein-protein interactions. Challenges and future prospects of this field are also discussed. ; National Basic Research Program of China [2015CB910300]; National High Technology Research and Development Program of China [2012AA020308]; National Natural Science Foundation of China [11021463] ; SCI(E) ; EI ; 中国科技核心期刊(ISTIC) ; REVIEW ; lhlai@pku.edu.cn ; 1 ; 310-316 ; 25 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1674-1056 1741-4199 |
| العلاقة: | CHINESE PHYSICS B.2016,25,(1).; 1391581; http://hdl.handle.net/20.500.11897/435607Test; WOS:000368455100096 |
| DOI: | 10.1088/1674-1056/25/1/018702 |
| الإتاحة: | https://doi.org/20.500.11897/435607Test https://doi.org/10.1088/1674-1056/25/1/018702Test https://hdl.handle.net/20.500.11897/435607Test |
| رقم الانضمام: | edsbas.6E62318 |
| قاعدة البيانات: | BASE |
| تدمد: | 16741056 17414199 |
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| DOI: | 10.1088/1674-1056/25/1/018702 |