دورية أكاديمية
Usefulness of human epididymis protein 4 in predicting cytoreductive surgical outcomes for advanced ovarian tubal and peritoneal carcinoma
| العنوان: | Usefulness of human epididymis protein 4 in predicting cytoreductive surgical outcomes for advanced ovarian tubal and peritoneal carcinoma |
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| المؤلفون: | Tang, Zhijian, Chang, Xiaohong, Ye, Xue, Li, Yi, Cheng, Hongyan, Cui, Heng |
| المساهمون: | Cui, H (reprint author), Peking Univ, Gynecol Oncol Ctr, Peoples Hosp, 11 Xizhimen S St, Beijing 100044, Peoples R China., Peking Univ, Gynecol Oncol Ctr, Peoples Hosp, Beijing 100044, Peoples R China., Peking Univ, Gynecol Oncol Ctr, Peoples Hosp, 11 Xizhimen S St, Beijing 100044, Peoples R China. |
| المصدر: | PubMed ; CSCD ; SCI ; 万方 ; 知网 |
| بيانات النشر: | CHINESE JOURNAL OF CANCER RESEARCH |
| سنة النشر: | 2015 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Human epididymis protein 4 (HE4), advanced epithelial ovarian cancer (EOC), optimal cytoreduction, CA125, PREOPERATIVE SERUM CA-125, NEOADJUVANT CHEMOTHERAPY, TUMOR CYTOREDUCTION, PROSPECTIVE TRIAL, CANCER, HE-4, SURGERY, ABILITY, SURVIVAL, DISEASE |
| الوصف: | Objective: Human epididymis protein 4 (HE4) is a promising biomarker of epithelial ovarian cancer (EOC). But its role in assessing the primary optimal debulking (OD) of EOC remains unknown. The purpose of this study is to elucidate the ability of preoperative HE4 in predicting the primary cytoreductive outcomes in advanced EOC, tubal or peritoneal carcinoma. Methods: We reviewed the records of 90 patients with advanced ovarian, tubal or peritoneal carcinoma who underwent primary cytoreduction at the Department of Obstetrics and Gynecology of Peking University People's Hospital between November 2005 and October 2010. Preoperative serum HE4 and CA125 levels were detected with EIA kit. A receiver operating characteristic (ROC) curve was used to determine the most useful HE4 cut-off value. Logistic regression analysis was performed to identify significant preoperative clinical characteristics to predict optimal primary cytoreduction. Results: OD was achieved in 47.7% (43/48) of patients. The median preoperative HE4 level for patients with OD vs. suboptimal debulking was 423 and 820 pmol/L, respectively (P<0.001). The areas under the ROC curve for HE4 and CA125 were 0.716 and 0.599, respectively (P=0.080). The most useful HE4 cut-off value was 473 pmol/L. Suboptimal cytoreduction was obtained in 66.7% (38/57) of cases with HE4 >= 473 pmol/L compared with only 27.3% (9/33) of cases with HE4 <473 pmol/L. At this threshold, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for diagnosing suboptimal debulking were 81%, 56%, 67%, and 73%, respectively. Logistic regression analysis showed that the patients with HE4 >= 473 pmol/L were less likely to achieve OD (odds ratio =5.044, P=0.002). Conclusions: Preoperative serum HE4 may be helpful to predict whether optimal cytoreductive surgery could be obtained or whether extended cytoreduction would be needed by an interdisciplinary team. ; the Specialized Research Fund for Doctoral Program of Higher Education,supported ... |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1000-9604 1993-0631 |
| العلاقة: | CHINESE JOURNAL OF CANCER RESEARCH.2015,27,(3),309-317.; 1491796; http://hdl.handle.net/20.500.11897/451384Test; WOS:000358873300011 |
| DOI: | 10.3978/j.issn.1000-9604.2015.06.01 |
| الإتاحة: | https://doi.org/20.500.11897/451384Test https://doi.org/10.3978/j.issn.1000-9604.2015.06.01Test https://hdl.handle.net/20.500.11897/451384Test |
| رقم الانضمام: | edsbas.51DF58B6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10009604 19930631 |
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| DOI: | 10.3978/j.issn.1000-9604.2015.06.01 |