دورية أكاديمية
Obesity-induced inflammatory miR-133a mediates apoptosis of granulosa cells and causes abnormal folliculogenesis
| العنوان: | Obesity-induced inflammatory miR-133a mediates apoptosis of granulosa cells and causes abnormal folliculogenesis |
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| المؤلفون: | Chen Ruizhi, Wu Xueqing, Qiu Han, Yang Baiming, Chen Yao, Chen Xiang, Li Yingshan, Yuan Shaochun, Liu Dan, Xiao Luanjuan, Yu Yanhong |
| المصدر: | Acta Biochimica et Biophysica Sinica, Vol 55, Pp 1234-1246 (2023) |
| بيانات النشر: | China Science Publishing & Media Ltd., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biochemistry LCC:Genetics |
| مصطلحات موضوعية: | abnormal follicular development, inflammation, miR-133a, obesity, Biochemistry, QD415-436, Genetics, QH426-470 |
| الوصف: | Obesity has been reported to promote disordered folliculogenesis, but the exact molecular mechanisms are still not fully understood. In this study, we find that miR-133a is involved in obesity-induced follicular development disorder. After feeding with a high-fat diet (HFD) and fructose water for nine weeks, the mouse body weight is significantly increased, accompanied by an inflammatory state and increased expression of miR-133a in the adipose tissues and ovaries as well as accelerated follicle depletion. Although miR-133a is increased in the fat and ovaries of HFD mice, the increased miR-133a in the HFD ovaries is not derived from exosome transferred from obese adipose tissues but is synthesized by ovarian follicular cells in response to HFD-induced inflammation. In vivo experiments show that intrabursal injection of miR-133a agomir induces a decrease in primordial follicles and an increase in antral follicles and atretic follicles, which is similar to HFD-induced abnormal folliculogenesis. Overexpression of miR-133a modestly promotes granulosa cell apoptosis by balancing the expression of anti-apoptotic proteins such as C1QL1 and XIAP and pro-apoptotic proteins such as PTEN. Overall, this study reveals the function of miR-133a in obesity-induced ovarian folliculogenesis dysfunction and sheds light on the etiology of female reproductive disorders. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1672-9145 |
| العلاقة: | https://doaj.org/toc/1672-9145Test |
| DOI: | 10.3724/abbs.2023089 |
| الوصول الحر: | https://doaj.org/article/d8f821773a734a67af33fedcec284456Test |
| رقم الانضمام: | edsdoj.8f821773a734a67af33fedcec284456 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16729145 |
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| DOI: | 10.3724/abbs.2023089 |