Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
| العنوان: | Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe |
|---|---|
| المؤلفون: | Villanueva A, Juan J. Pasantes, Roman-Lewis Cf, D. Costas, Ricardo F, A. Pequeno, Sara Rocha, Jorge Rodríguez-Castro, Daniel García-Souto, Cetinic Ab, David Posada, Diaz S, Tarallo A, Alonso J, Giovanni Annona, L. M. Silva, Tubio Jmc, Alicia L. Bruzos, Rodriguez R, Valencia Jm |
| المساهمون: | Metzger, M.J. (Michael J), European Commission, Ministerio de Economía y Competitividad (España), Xunta de Galicia, Centro de Estudos do Ambiente e do Mar (Portugal), Garcia-Souto, Daniel, Bruzos, Alicia L, Diaz, Seila, Rocha, Sara, Pequeño-Valtierra, Ana, Roman-Lewis, Camila F, Costas, Damian, Rodriguez-Castro, Jorge, Valencia, Jose Maria, Annona, Giovanni, Tarallo, Andrea, Bratoš Cetinić, Ana, Posada, David, Pasantes, Juan Jose, Tubio, Jose Mc, Garcia-Souto, Daniel [0000-0002-0997-8799], Bruzos, Alicia L [0000-0003-4362-545X], Diaz, Seila [0000-0002-6607-290X], Rocha, Sara [0000-0002-9705-1511], Pequeño-Valtierra, Ana [0000-0002-0049-5707], Roman-Lewis, Camila F [0000-0002-8571-8331], Costas, Damian [0000-0002-9415-0362], Rodriguez-Castro, Jorge [0000-0003-2912-9601], Valencia, Jose Maria [0000-0002-1912-1975], Annona, Giovanni [0000-0001-7806-6761], Tarallo, Andrea [0000-0002-2749-8588], Bratoš Cetinić, Ana [0000-0002-2928-4858], Posada, David [0000-0003-1407-3406], Pasantes, Juan Jose [0000-0001-6515-3946], Tubio, Jose Mc [0000-0003-3540-2459] |
| المصدر: | e-IEO. Repositorio Institucional Digital de Acceso Abierto del Instituto Español de Oceanografía instname bioRxiv eLife, Vol 11 (2022) eLife Digital.CSIC. Repositorio Institucional del CSIC |
| بيانات النشر: | Centro Oceanográfico de Cádiz, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | medicine, Lineage (evolution), 0302 clinical medicine, Mediterranean sea, genetics, Pesquerías, Biology (General), cancer genomes, Cancer (genus), 0303 health sciences, Hemic neoplasia, Leukemia, Ecology, biology, General Neuroscience, General Medicine, 3. Good health, Medicine, transmissible cancer, Cancer genomes, Warty venus, Mitochondrial DNA, animal structures, Nuclear gene, QH301-705.5, Science, Cancer biology, Short Report, Zoology, Venus, Centro Oceanográfico de Cádiz, Marine leukaemias, DNA, Mitochondrial, General Biochemistry, Genetics and Molecular Biology, diseases, 03 medical and health sciences, Mediterranean Sea, Animals, 14. Life underwater, Transmissible cancer, 030304 developmental biology, marine leukaemias, research, Whole Genome Sequencing, General Immunology and Microbiology, Clam. genome, cancer, mitochondrial, zoology, Haplotype, Sequence Analysis, DNA, biology.organism_classification, Bivalvia, Spain, Genome, Mitochondrial, Other, 030217 neurology & neurosurgery |
| الوصف: | 20 Pág. Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the transfer of living cancer cells. In marine bivalves, leukaemia-like transmissible cancers, called hemic neoplasia (HN), have demonstrated the ability to infect individuals from different species. We performed whole-genome sequencing in eight warty venus clams that were diagnosed with HN, from two sampling points located more than 1000 nautical miles away in the Atlantic Ocean and the Mediterranean Sea Coasts of Spain. Mitochondrial genome sequencing analysis from neoplastic animals revealed the coexistence of haplotypes from two different clam species. Phylogenies estimated from mitochondrial and nuclear markers confirmed this leukaemia originated in striped venus clams and later transmitted to clams of the species warty venus, in which it survives as a contagious cancer. The analysis of mitochondrial and nuclear gene sequences supports all studied tumours belong to a single neoplastic lineage that spreads in the Seas of Southern Europe. We thank the Galicia Supercomputing Centre (CESGA) for the availability of informatic resources. JMCT, SR, SD, and JT are supported by European Research Council (ERC) Starting Grant 716,290 SCUBA CANCERS. ALB is supported by MINECO PhD fellowship BES-2016-078166. DG-S is supported by postdoctoral contract ED481B/2018/091 from Xunta de Galicia. DP is supported by ERC grant ERC-617457-PHYLOCANCER and by Spanish Ministry of Economy and Competitiveness (MINECO) grant PID2019-106247GB-I00. This research was partially funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement 730984, ASSEMBLE Plus project. CESAM got financial support from FCT/MEC (UIDP/50017/2020, UIDB/50017/2020). |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb5da82708667881298167a5fdab3a0Test http://hdl.handle.net/10508/15701Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4cb5da82708667881298167a5fdab3a0 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |