Calculus in the male urethra is a rare clinical presentation and case reports of urethral calculi in the medical literature are likewise scant. We report a case of a 33-year-old male who presented at Delhi Govt Homoeopathic Dispensary at Aali Village with intense pain and scanty urination. Ultrasonography confirmed the diagnosis of urethral calculus in prostatic part of urethra. On the basis of keynotes, Lyssin prescribed in LM potencies improved urinary flow immediately and provided pain relief, which were objectively assessed as per pre-defined scales, and the 11 mm calculus was expelled in 8 days. No complication was observed during the following 6 months with after expulsion of a large calculus.
