Maternal Malaria and Perinatal HIV Transmission, Western Kenya1,2
| العنوان: | Maternal Malaria and Perinatal HIV Transmission, Western Kenya1,2 |
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| المؤلفون: | Robert D. Newman, Margarette S. Kolczak, John G. Ayisi, Juliana A. Otieno, Chunfu Yang, Richard W. Steketee, Ya Ping Shi, Feiko O. ter Kuile, Ambrose O. Misore, Anna Maria van Eijk, Renu B. Lal, Piet A. Kager, Bernard L. Nahlen |
| المصدر: | Emerging Infectious Diseases |
| بيانات النشر: | Centers for Disease Control and Prevention (CDC), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Microbiology (medical), Episiotomy, medicine.medical_specialty, placenta, Epidemiology, medicine.medical_treatment, malaria, HIV Infections, Perinatal hiv, Immune system, Pregnancy, Risk Factors, parasitic diseases, Perineal tear, medicine, Humans, vertical disease transmission, Obstetrics, Transmission (medicine), business.industry, Research, Infant, Newborn, HIV, virus diseases, medicine.disease, Kenya, Infectious Disease Transmission, Vertical, Infectious Diseases, Pregnancy Complications, Parasitic, Africa, Multivariate Analysis, Female, business, Viral load, Malaria |
| الوصف: | To determine whether maternal placental malaria is associated with an increased risk for perinatal mother-to-child HIV transmission (MTCT), we studied HIV-positive women in western Kenya. We enrolled 512 mother-infant pairs; 128 (25.0%) women had placental malaria, and 102 (19.9%) infants acquired HIV perinatally. Log10 HIV viral load and episiotomy or perineal tear were associated with increased perinatal HIV transmission, whereas low-density placental malaria (10,000 parasites/mL) was associated with reduced risk (adjusted relative risk [ARR] 0.4). Among women dually infected with malaria and HIV, high-density placental malaria (10,000 parasites/mL) was associated with increased risk for perinatal MTCT (ARR 2.0), compared to low-density malaria. The interaction between placental malaria and MTCT appears to be variable and complex: placental malaria that is controlled at low density may cause an increase in broad-based immune responses that protect against MTCT; uncontrolled, high-density malaria may simultaneously disrupt placental architecture and generate substantial antigen stimulus to HIV replication and increase risk for MTCT. |
| تدمد: | 1080-6059 1080-6040 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02845d94ada9fdbe6be494ca619f2ad4Test https://doi.org/10.3201/eid1004.030303Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....02845d94ada9fdbe6be494ca619f2ad4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
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