Rotavirus Serotype G9P[8] and Acute Gastroenteritis Outbreak in Children, Northern Australia
| العنوان: | Rotavirus Serotype G9P[8] and Acute Gastroenteritis Outbreak in Children, Northern Australia |
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| المؤلفون: | Graeme L. Barnes, Ruth F. Bishop, Carl D. Kirkwood, Nada Bogdanovic-Sakran |
| المصدر: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 10, Iss 9, Pp 1593-1600 (2004) |
| بيانات النشر: | Centers for Disease Control and Prevention (CDC), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Male, Rotavirus, Microbiology (medical), Serotype, Time Factors, Epidemiology, viruses, lcsh:Medicine, Biology, medicine.disease_cause, serotype G9, Rotavirus Infections, lcsh:Infectious and parasitic diseases, Disease Outbreaks, law.invention, Microbiology, law, medicine, Humans, lcsh:RC109-216, acute gastroenteritis, Serotyping, Child, Antigens, Viral, Polymerase chain reaction, Molecular Epidemiology, Sequence Homology, Amino Acid, Molecular epidemiology, Research, lcsh:R, Australia, virus diseases, Outbreak, biochemical phenomena, metabolism, and nutrition, Acute gastroenteritis, Virology, Gastroenteritis, Infectious Diseases, Northern australia, Capsid Proteins, Female, Influence function |
| الوصف: | Amino acid substitutions on the VP7 and NSP4 proteins were identified in regions known to influence function and may have contributed to the emergence and increased dominance of the outbreak strains. During 2001, an outbreak of severe acute gastroenteritis swept through Central and northern Australia and caused serious disruption to health services. We tracked and characterized the rotavirus strain implicated in the outbreak. Comparison of the electropherotypes of outbreak samples suggested that one G9P[8] strain was likely responsible for the outbreak. Samples were obtained from geographically distinct regions of Australia where the epidemic had occurred. The outbreak strains showed identical nucleotide sequences in genes encoding three rotavirus proteins, VP7, VP8, and NSP4, but they were distinct from G9P[8] strains isolated in previous years. Several of the amino acid substitutions on the VP7 and NSP4 proteins were identified in regions known to influence function and may have contributed to the emergence and increased dominance of the outbreak strains. Rotavirus serotype surveillance should continue with methods capable of identifying new and emerging types. |
| تدمد: | 1080-6059 1080-6040 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e5f527ea1f954142ee5993889609daTest https://doi.org/10.3201/eid1009.040040Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....38e5f527ea1f954142ee5993889609da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
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