دورية أكاديمية
Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986-2018
| العنوان: | Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986-2018 |
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| المؤلفون: | Mir-Cros, Alba, Moreno-Mingorance, Albert, Martín-Gómez, M Teresa, Abad, Raquel, Bloise, Iván, Campins, Magda, González-Praetorius, Alejandro, Gutiérrez, M Nieves, Martín-González, Héctor, Muñoz-Almagro, Carmen, Orellana, M Ángeles, de Pablos, Manuela, Roca-Grande, Josep, Rodrigo, Carlos, Rodríguez, M Elena, Uriona, Sonia, Vidal, M José, Pumarola, Tomàs, Larrosa, M Nieves, González-López, Juan José |
| المساهمون: | Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), RETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España), Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR), Vall d´Hebron Institut de Recerca |
| بيانات النشر: | Centers for Disease Control and Prevention (CDC) |
| سنة النشر: | 2022 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | Bordetella pertussis, Spain, Bacteria, Pertussis vaccine, Phylogenetic evolution, Virulence factors, Whooping cough, Bacterial Outer Membrane Proteins, Humans, Phylogeny, Bordetella |
| الوصف: | Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481. To assess the effect of the transition from whole-cell vaccine to ACV on the emergence of B. pertussis not expressing pertactin in Spain, we studied 342 isolates collected during 1986-2018. We identified 93 pertactin-deficient isolates. All were detected after introduction of ACV and represented 38% of isolates collected during the ACV period; 58.1% belonged to a genetic cluster of isolates carrying the unusual prn::del(-292, 1340) mutation. Pertactin inactivation by IS481 insertion was identified in 23.7% of pertactin-deficient isolates, arising independently multiple times and in different phylogenetic branches. Our findings support the emergence and dissemination of a cluster of B. pertussis with an infrequent mechanism of pertactin disruption in Spain, probably resulting from introduction of ACV. ; This work was supported by the Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, and cofinanced by the European Regional Development Fund “A Way to Achieve Europe” (Spanish Network for Research in Infectious Diseases, grant no. FIS PI18/00703) and by the Centro de Investigación Biomédica en Red (CIBER de Enfermedades Infecciosas), the Red Española de Investigación en Patología Infecciosa (grant no. CB21/13/00054). A.M.C. is supported by the Agència de Gestió d’Ajuts Universitaris i de Recerca de la Generalitat de Catalunya at Vall d’Hebron Institut de Recerca (Ajuts per a la Contractació de Personal Investigador FI, grant no. 2020FI_B2_00145) and by the Spanish Network for Research in Infectious Diseases (grant no. RD16/ 0016/0003). A.M.M. is supported by a grant from the Fondo de Investigación Sanitaria at Vall d’Hebron Institut de Recerca (Contratos Predoctorales de Formación en Investigación, grant no. FI19/00315). ; Sí |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1080-6059 |
| العلاقة: | https://doi.org/10.3201/eid2805.211958Test; info:eu-repo/grantAgreement/ES/RD16/0016/0003; info:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/PI18 - Proyectos de investigacion en salud (AES 2018). Modalidad proyectos en salud. (2018)/PI18/00703; info:eu-repo/grantAgreement/ES/CB21/13/00054; Emerg Infect Dis. 2022 May;28(5):967-976.; http://hdl.handle.net/20.500.12105/16022Test; Emerging infectious diseases |
| DOI: | 10.3201/eid2805.211958 |
| الإتاحة: | https://doi.org/20.500.12105/16022Test https://doi.org/10.3201/eid2805.211958Test https://hdl.handle.net/20.500.12105/16022Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; Atribución 4.0 Internacional ; open access |
| رقم الانضمام: | edsbas.FC74939B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10806059 |
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| DOI: | 10.3201/eid2805.211958 |