دورية أكاديمية
IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
| العنوان: | IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
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| المؤلفون: | Staines, Henry M., Kirwan, Daniela E., Clark, David J., Adams, Emily R., Augustin, Yolanda, Byrne, Rachel L., Cocozza, Michael, Cubas-Atienzar, Ana I., Cuevas, Luis E., Cusinato, Martina, Davies, Benedict M.O., Davis, Mark, Davis, Paul, Duvoix, Annelyse, Eckersley, Nicholas M., Forton, Daniel, Fraser, Alice J., Garrod, Gala, Hadcocks, Linda, Hu, Qinxue, Johnson, Michael, Kay, Grant A, Klekotko, Kesja, Lewis, Zawditu, Macallan, Derek C., Mensah-Kane, Josephine, Menzies, Stefanie, Monahan, Irene, Moore, Catherine M., Nebe-von-Caron, Gerhard, Owen, Sophie I., Sainter, Chris, Sall, Amadou A., Schouten, James, Williams, Christopher T., Wilkins, John, Woolston, Kevin, Fitchett, Joseph R.A., Krishna, Sanjeev, Planche, Tim |
| بيانات النشر: | Centers for Disease Control and Prevention |
| سنة النشر: | 2021 |
| المجموعة: | University of Westminster: WestminsterResearch |
| الوصف: | We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29–May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS-CoV-2 infection. We measured IgG against SARS-CoV-2 and compared antibody levels with patient outcomes, demographic information, and laboratory characteristics. We found that 2.0%–8.5% of persons did not seroconvert 3–6 weeks after infection. Persons who seroconverted were older, were more likely to have concurrent conditions, and had higher levels of inflammatory markers. Non-White persons had higher antibody concentrations than those who identified as White; these concentrations did not decline during follow-up. Serologic assay results correlated with disease outcome, race, and other risk factors for severe SARS-CoV-2 infection. Serologic assays can be used in surveillance to clarify the duration and protective nature of humoral responses to SARS-CoV-2 infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://doi.org/10.3201/eid2701.203074Test; Staines, Henry M., Kirwan, Daniela E., Clark, David J., Adams, Emily R., Augustin, Yolanda, Byrne, Rachel L., Cocozza, Michael, Cubas-Atienzar, Ana I., Cuevas, Luis E., Cusinato, Martina, Davies, Benedict M.O., Davis, Mark, Davis, Paul, Duvoix, Annelyse, Eckersley, Nicholas M., Forton, Daniel, Fraser, Alice J., Garrod, Gala, Hadcocks, Linda, Hu, Qinxue, Johnson, Michael, Kay, Grant A, Klekotko, Kesja, Lewis, Zawditu, Macallan, Derek C., Mensah-Kane, Josephine, Menzies, Stefanie, Monahan, Irene, Moore, Catherine M., Nebe-von-Caron, Gerhard, Owen, Sophie I., Sainter, Chris, Sall, Amadou A., Schouten, James, Williams, Christopher T., Wilkins, John, Woolston, Kevin, Fitchett, Joseph R.A., Krishna, Sanjeev and Planche, Tim 2021. IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Emerging Infectious Diseases. 27 (1), pp. 85-91. https://doi.org/10.3201/eid2701.203074Test |
| DOI: | 10.3201/eid2701.203074 |
| الإتاحة: | https://doi.org/10.3201/eid2701.203074Test https://westminsterresearch.westminster.ac.uk/item/w3648/igg-seroconversion-and-pathophysiology-in-severe-acute-respiratory-syndrome-coronavirus-2-infectionTest |
| رقم الانضمام: | edsbas.2B989C4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3201/eid2701.203074 |
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