Effects of Green Tea Catechin on Phospholipase A2 Activity and Antithrombus in Streptozotocin Diabetic Rats
| العنوان: | Effects of Green Tea Catechin on Phospholipase A2 Activity and Antithrombus in Streptozotocin Diabetic Rats |
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| المؤلفون: | Jeong-Ah Yang, Jeong-Hwa Choi, Soon-Jae Rhee |
| المصدر: | Journal of Nutritional Science and Vitaminology. 45:337-346 |
| بيانات النشر: | Center for Academic Publications Japan, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Blood Platelets, Male, medicine.medical_specialty, Platelet Aggregation, Medicine (miscellaneous), Prostacyclin, Thiobarbituric Acid Reactive Substances, Catechin, Phospholipases A, Diabetes Mellitus, Experimental, Rats, Sprague-Dawley, Thromboxane A2, chemistry.chemical_compound, Phospholipase A2, Internal medicine, medicine, Animals, Platelet, Aorta, Nutrition and Dietetics, Tea, biology, Thrombosis, Streptozotocin, Epoprostenol, Rats, Phospholipases A2, Endocrinology, Eicosanoid, chemistry, Prostaglandin-Endoperoxide Synthases, biology.protein, Thromboxane-A Synthase, Cyclooxygenase, medicine.drug |
| الوصف: | The purpose of this study was to investigate the effects of dietary green tea catechin on phospholipase A2 (PLA2) activity and the antithrombotic reaction of platelets in streptozotocin (STZ)-diabetic rats. Sprague-Dawley male rats weighing 100 +/- 10 g were randomly divided into one normal and three STZ-diabetic groups, which were subdivided into catechin-free group (DM-0C), 0.5% catechin group (DM-0.5C) and 1% catechin group (DM-1C). The activity level of platelet phospholipase A2 was higher in the diabetic groups than in the normal group, while it was lower in DM-0.5C and DM-1C than in DM-0C. The activity of platelet cyclooxygenase in DM-0C was 1.1-fold as high as in the normal group, but was significantly reduced by catechin supplementation. The platelet thromboxane A2 (TXA2) formation became higher in DM-0C as compared to the normal group, but not in DM-0.5C and DM-1C. The synthesis of aortic prostacyclin (PGI2) was lower in DM-0C and DM-0.5C than in the normal group. The PGI2/TXA2 ratio was decreased to 55% in DM-0C, but was restored by catechin supplementation. These results indicate that STZ-diabetic rats are sensitive to platelet aggregation and thrombosis, and that the abnormality can be improved by dietary catechin. |
| تدمد: | 1881-7742 0301-4800 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ecb0854044e5ad16e450175f574355Test https://doi.org/10.3177/jnsv.45.337Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....17ecb0854044e5ad16e450175f574355 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18817742 03014800 |
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