XPD Mutations Prevent TFIIH-Dependent Transactivation by Nuclear Receptors and Phosphorylation of RARα
| العنوان: | XPD Mutations Prevent TFIIH-Dependent Transactivation by Nuclear Receptors and Phosphorylation of RARα |
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| المؤلفون: | Cécile Rochette-Egly, Alain Sarasin, Anne Stary, Jean-Marc Egly, Anne Keriel |
| المساهمون: | Institut National de la Santé et de la Recherche Médicale (INSERM), Etude des relations instabilité génétique et cancer (ERIGC), Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I |
| المصدر: | Cell Cell, Elsevier, 2002, 109 (1), pp.125-35 |
| بيانات النشر: | Cell Press. |
| مصطلحات موضوعية: | MESH: Signal Transduction, Transcription, Genetic, Receptors, Retinoic Acid, Receptors, Cytoplasmic and Nuclear, MESH: DNA Helicases, Transactivation, Transcription Factors, TFII, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Animals, MESH: Proteins, Phosphorylation, MESH: Retinoic Acid Receptor alpha, MESH: Transcription Factor TFIIH, Retinoic Acid Receptor alpha, MESH: Transcription Factors, MESH: Xeroderma Pigmentosum Group D Protein, MESH: Gene Expression Regulation, Cyclin-Dependent Kinases, DNA-Binding Proteins, MESH: Cyclin-Dependent Kinases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Transcription factor II H, Signal transduction, Signal Transduction, Transcriptional Activation, MESH: Cell Nucleus, Xeroderma pigmentosum, MESH: Mutation, Biology, Protein Serine-Threonine Kinases, MESH: Receptors, Cytoplasmic and Nuclear, General Biochemistry, Genetics and Molecular Biology, MESH: Protein-Serine-Threonine Kinases, MESH: Transcription Factors, TFII, medicine, Animals, Humans, Transcription factor, Xeroderma Pigmentosum Group D Protein, MESH: Xeroderma Pigmentosum, Cell Nucleus, MESH: Receptors, Retinoic Acid, Xeroderma Pigmentosum, MESH: Humans, MESH: Phosphorylation, Biochemistry, Genetics and Molecular Biology(all), MESH: Transcription, Genetic, DNA Helicases, Proteins, Fibroblasts, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Transcription Factor TFIIH, Nuclear receptor, Gene Expression Regulation, MESH: Fibroblasts, Mutation, MESH: HeLa Cells, Cancer research, MESH: Transcriptional Activation, Cyclin-dependent kinase 7, Cyclin-Dependent Kinase-Activating Kinase, MESH: DNA-Binding Proteins, HeLa Cells, Transcription Factors |
| الوصف: | International audience; Inherited mutations in the XPD subunit of the general transcription/repair factor TFIIH yield the rare genetic disorder Xeroderma pigmentosum (XP), the phenotypes of which cannot be explained solely on the basis of a DNA repair defect. In cells derived from XP-D patients, we observed a reduction of the ligand-dependent transactivation mediated by several nuclear receptors (RARalpha, ERalpha, and AR). We demonstrate that the XPD mutation alters cdk7 function in RARalpha phosphorylation. Transactivation is restored upon overexpression of either the wild-type XPD or the RARalphaS77E (a mutation which mimics phosphorylated RARalpha). Thus, we demonstrate that the cdk7 kinase of TFIIH phosphorylates the nuclear receptor, then allowing ligand-dependent control of the activation of the hormone-responsive genes. |
| اللغة: | English |
| تدمد: | 0092-8674 1097-4172 |
| DOI: | 10.1016/S0092-8674(02)00692-X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63296d627297e6f98d9a770eceff6c54Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....63296d627297e6f98d9a770eceff6c54 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00928674 10974172 |
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| DOI: | 10.1016/S0092-8674(02)00692-X |