دورية أكاديمية
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
| العنوان: | 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development |
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| المؤلفون: | Wang, Ting, Wang, Zheng, de Fabritus, Lauriane, Tao, Jinglian, Saied, Essa M, Lee, Ho-Joon, Ramazanov, Bulat R, Jackson, Benjamin, Burkhardt, Daniel, Parker, Mikhail, Gleinich, Anne S, Wang, Zhirui, Seo, Dong Eun, Zhou, Ting, Xu, Shihao, Alecu, Irina, Azadi, Parastoo, Arenz, Christoph, Hornemann, Thorsten, Krishnaswamy, Smita, van de Pavert, Serge A, Kaech, Susan M, Ivanova, Natalia B, Santori, Fabio R |
| المصدر: | Wang, Ting; Wang, Zheng; de Fabritus, Lauriane; Tao, Jinglian; Saied, Essa M; Lee, Ho-Joon; Ramazanov, Bulat R; Jackson, Benjamin; Burkhardt, Daniel; Parker, Mikhail; Gleinich, Anne S; Wang, Zhirui; Seo, Dong Eun; Zhou, Ting; Xu, Shihao; Alecu, Irina; Azadi, Parastoo; Arenz, Christoph; Hornemann, Thorsten; Krishnaswamy, Smita; van de Pavert, Serge A; Kaech, Susan M; Ivanova, Natalia B; Santori, Fabio R (2021). 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development. Developmental Cell, 56(22):3128-3145.e15. |
| بيانات النشر: | Cell Press (Elsevier) |
| سنة النشر: | 2021 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Institute of Clinical Chemistry, 610 Medicine & health, 540 Chemistry |
| الوصف: | Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and products, we identify 1-deoxysphingosines as modulators of the activity of NR2F1 and 2 (COUP-TFs), which are orphan NHRs that are critical for development of the nervous system, heart, veins, and lymphatic vessels. We show that these non-canonical alanine-based sphingolipids bind to the NR2F1/2 ligand-binding domains (LBDs) and modulate their transcriptional activity in cell-based assays at physiological concentrations. Furthermore, inhibition of sphingolipid biosynthesis phenocopies NR2F1/2 deficiency in endothelium and cardiomyocytes, and increases in 1-deoxysphingosine levels activate NR2F1/2-dependent differentiation programs. Our findings suggest that 1-deoxysphingosines are physiological regulators of NR2F1/2-mediated transcription. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1534-5807 |
| العلاقة: | https://www.zora.uzh.ch/214507Test; info:pmid/34762852; urn:issn:1534-5807 |
| DOI: | 10.1016/j.devcel.2021.10.018 |
| الإتاحة: | https://doi.org/10.1016/j.devcel.2021.10.018Test https://www.zora.uzh.ch/id/eprint/214507Test/ https://www.zora.uzh.ch/214507Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.56E02F15 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15345807 |
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| DOI: | 10.1016/j.devcel.2021.10.018 |