دورية أكاديمية
Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver
| العنوان: | Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver |
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| المؤلفون: | Bertocchi, Alice, Carloni, Sara, Ravenda, Paola Simona, Bertalot, Giovanni, Spadoni, Ilaria, Lo Cascio, Antonino, Gandini, Sara, Lizier, Michela, Braga, Daniele, Asnicar, Francesco, Segata, Nicola, Klaver, Chris, Brescia, Paola, Rossi, Elio, Anselmo, Achille, Guglietta, Silvia, Maroli, Annalisa, Spaggiari, Paola, Tarazona, Noelia, Cervantes, Andres, Marsoni, Silvia, Lazzari, Luca, Jodice, Maria Giovanna, Luise, Chiara, Erreni, Marco, Pece, Salvatore, Di Fiore, Pier Paolo, Viale, Giuseppe, Spinelli, Antonino, Pozzi, Chiara, Penna, Giuseppe, Rescigno, Maria |
| المساهمون: | A. Bertocchi, S. Carloni, P.S. Ravenda, G. Bertalot, I. Spadoni, A. Lo Cascio, S. Gandini, M. Lizier, D. Braga, F. Asnicar, N. Segata, C. Klaver, P. Brescia, E. Rossi, A. Anselmo, S. Guglietta, A. Maroli, P. Spaggiari, N. Tarazona, A. Cervante, S. Marsoni, L. Lazzari, M.G. Jodice, C. Luise, M. Erreni, S. Pece, P.P. Di Fiore, G. Viale, A. Spinelli, C. Pozzi, G. Penna, M. Rescigno |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2021 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Escherichia coli, bacteria, colorectal cancer, gut vascular barrier, inflammatory monocyte, macrophage, metastase, neutrophil, premetastatic niche, vasculature, Settore MED/04 - Patologia Generale, Settore BIO/19 - Microbiologia Generale, Settore BIO/11 - Biologia Molecolare |
| الوصف: | Metastasis is facilitated by the formation of a "premetastatic niche," which is fostered by primary tumor-derived factors. Colorectal cancer (CRC) metastasizes mainly to the liver. We show that the premetastatic niche in the liver is induced by bacteria dissemination from primary CRC. We report that tumor-resident bacteria Escherichia coli disrupt the gut vascular barrier (GVB), an anatomical structure controlling bacterial dissemination along the gut-liver axis, depending on the virulence regulator VirF. Upon GVB impairment, bacteria disseminate to the liver, boost the formation of a premetastatic niche, and favor the recruitment of metastatic cells. In training and validation cohorts of CRC patients, we find that the increased levels of PV-1, a marker of impaired GVB, is associated with liver bacteria dissemination and metachronous distant metastases. Thus, PV-1 is a prognostic marker for CRC distant recurrence and vascular impairment, leading to liver metastases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33798472; info:eu-repo/semantics/altIdentifier/wos/WOS:000652032200018; volume:39; issue:5; firstpage:708; lastpage:724.e11; numberofpages:17; journal:CANCER CELL; http://hdl.handle.net/2434/830631Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85104557875 |
| DOI: | 10.1016/j.ccell.2021.03.004 |
| الإتاحة: | https://doi.org/10.1016/j.ccell.2021.03.004Test http://hdl.handle.net/2434/830631Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.E6E64226 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ccell.2021.03.004 |
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