دورية أكاديمية
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
| العنوان: | The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis |
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| المؤلفون: | Cowley, M. A., Smith, Roy G., Diano, S., Tschöp, Matthias, Pronchuk, Nina, Grove, K. L., Strasburger, Christian J., Bidlingmaier, M., Esterman, M., Heiman, M. L., García-Segura, Luis M., Nillni, E. A., Méndez, Pablo, Low, M. J., Sotonyi, Peter, Friedman, J. M., Liu, H., Pinto, S., Colmers, W. F., Cone, R. D., Horvath, T. L. |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2003 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| الوصف: | The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized group of neurons adjacent to the third ventricle between the dorsal, ventral, paraventricular, and arcuate hypothalamic nuclei. These neurons send efferents onto key hypothalamic circuits, including those producing neuropeptide Y (NPY), Agouti-related protein (AGRP), proopiomelanocortin (POMC) products, and corticotropin-releasing hormone (CRH). Within the hypothalamus, ghrelin bound mostly on presynaptic terminals of NPY neurons. Using electrophysiological recordings, we found that ghrelin stimulated the activity of arcuate NPY neurons and mimicked the effect of NPY in the paraventricular nucleus of the hypothalamus (PVH). We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis. ; Peer Reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0896-6273 |
| العلاقة: | Neuron 37: 649-661 (2003); http://hdl.handle.net/10261/72120Test |
| DOI: | 10.1016/S0896-6273(03)00063-1 |
| الإتاحة: | https://doi.org/10.1016/S0896-6273Test(03)00063-1 http://hdl.handle.net/10261/72120Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.8AFF495F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 08966273 |
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| DOI: | 10.1016/S0896-6273(03)00063-1 |